双膦酸盐性颌骨坏死的临床诊断与治疗

Clinical diagnosis and treatment on bisphosphonate-related osteonecrosis of the jaw

双膦酸盐性颌骨坏死(bisphosphonate-related osteonecrosis of the jaw,BRONJ)是一类因长期使用唑来膦酸、帕米膦酸钠等双膦酸盐类药物所导致的药物并发症。它主要表现为服用双膦酸盐类药物的患者因拔牙等口内手术操作或自发地出现颌骨创口长期不愈、死骨暴露、局部软组织肿胀伴疼痛流脓等症状,影像学特点主要表现为局部片状骨密度增高影及不规则骨破坏影,且随着病变进展越发明显。目前对于该病的诊断及治疗仍未达成一致,笔者就近年来BRONJ的临床研究进展作一阐述。

Bisphosphonate?related osteonecrosis of the jaw(BRONJ)is a class of disease due to complications oflong?term use of bisphosphonates drugs such as zoledronic acid,phosphoric acid,etc.It is mainly manifested in themouth as a result of tooth extraction or appearing spontaneously mandibular long?term healing wounds,sequestrum expo?sure,local soft tissue swelling with pain and pus,etc.The X?ray showed irregular bone destruction and bone sclerosis asthe lesions progress.At present,the diagnosis and treatment of the disease has not reached agreement.In this paper,clinical diagnosis and treatment on BRONJ in recent years were reviewed.