中西药结合治疗消化性溃疡的临床研究

A study on treating peptic ulcer in the integrative medicine

目的:探讨中西药物结合治疗消化性溃疡的疗效及抗复发作用。方法:选取我院2011-2012年期间治疗的消化性溃疡患者90例,随机分为三组:中药组30例,中西药组30例,西药组30例,分别给予益气和胃胶囊、益气和胃胶囊+奥美拉唑、奥美拉唑,观察期均为3个月,采用放射免疫法,检测治疗前后患者血清及内镜下钳取黏膜组织中的EGF和PGE_2含量。结果:中西药物结合治疗后,胃镜疗效(86.7%)及6、9个月溃疡复发率控制均优于中药组和西药组,组间比较差异有统计学意义(P<0.05);血清及黏膜EGF和PGE_2含量均显著增加,三组比较总体差异有统计学意义(P<0.05)。结论:提高溃疡愈合质量,增加血清及黏膜EGF和PGE_2含量是中西药物结合抗消化性溃疡复发的关键。

Objective: To explore anti-relapse and effects of the integrative medicine on peptic ulcer. Methods: 90 patients were randomly divided into the TCM medicine group, the integrative medicine group and the western medicine group, 30 cases in each. The TCM medicine group was given the Yiqi Hewei capsules; the integrative medicine group was treated with the Yiqi Hewei capsules plus omeprazole; the western medicine group was treated with omeprazole, for 3 months. According to RIA, the blood serum, EGF and PGE2 of mucosal tissue in groups were examined. Results: The efficiency of endoscopy (86.7%) and the recurrence rate of ulcer in 6 months and 9 months were better in the integrative medicine group, with a statistically significant difference (P<0.05). The blood serum, EGF and PGE2 of mucosal tissue were significantly increased; and there were statistically significant differences among three groups (P<0.05). Conclusion:The integrative medicine can improve the quality of ulcers, increased serum and mucosal EGF and PGE2 content.