摘要
目的:观察PEG IFNα-2a联合康艾注射液对HBeAg(+)慢性乙型肝炎患者的抗病毒效果。方法:选取2010年1月—2014年1月在肇庆市中医院接受治疗HBeAg(+)慢性乙型肝炎患者共70例,依据随机数字表法将这些患者平均分为两组,对照组35(脱落3例)例,给予PEG IFNα-2a治疗48周,治疗组35例,在对照组治疗基础上给予康艾注射液治疗。分别观察两组病例治疗前、治疗后12周、24周、48周及停药后24周时的临床表现、肝功能、病毒学应答、HBeAg血清学转换、完全应答及HBs Ag定量变化情况。结果:治疗组总有效率96.67%,明显高于对照组的80.00%(P<0.01),治疗组比对照组能更早实现肝功能复常及病毒学应答(P<0.05);停药24周后,治疗组HBeAg血清学转换率为60.00%明显高于对照组的34.38%(P>0.05),治疗组完全应答率为22.86%明显高于对照组的6.25%(P<0.01)。结论:PEG IFNα-2a联合康艾注射液较单独使用PEG IFNα-2a治疗HBeAg(+)的慢性乙型肝炎能取得更好的抗病毒效果。
Objective:To observe the anti viral effect of PEG IFNα-2a combined with Kangai Injection in treating HBeAg-positive chronic Hepatitis B.Methods:70patients with HBeAg-positive chronic hepatitis B(CHB)treated in Zhaoqing Hospital of traditional Chinese medicine from January2010to January2014,were randomly divided evenly into two groups according to the random number table method.The control group(3cases dropped)was treated with PEG IFNα-2a for48weeks.The treatment group(35cases)was treated with Kangai injection on the basis of treatment of the control group.The clinical manifestation,the liver function,virologicalresponse,HBeAg seroconversion,completely viral response and quantitative change of HBsAg were observed before treatment and12weeks,24weeks and48weeks after treatment and24weeks after withdrawal.Results:After48weeks treatment,the total effective rate ofthe treatment group was96.67%,which was significantly higher than that of the group(80.00%)(P<0.01),and in the treatment group,therecovery of the liver function and virological response were shorter than that of the control group(P<0.05).24weeks after with drawal,therates of HBeAg serological conversion and complete viral response in the treatment group were60.00%and22.86%,which were significantly higher than those in the control group,22.86%and6.25%(P<0.05).Conclusion:PEG IFNα-2a combined with Kangai injection could achieve better antiviral effect in the treatment of HBeAg-positive CHB.
出处
《中医临床研究》
2017年第3期17-20,共4页
Clinical Journal Of Chinese Medicine
