原发性肝癌TACE术后急性肿瘤溶解综合征一例

A case of acute tumor lysis syndrome after TACE operation for primary liver cancer

肿瘤溶解综合征(TLS)是肿瘤细胞快速溶解后细胞内容物及其代谢产物迅速释放入血,引起一系列以高尿酸、高钾、高磷、低钙血症、急性肾功能不全为特征的并发症;TLS常见于对化疗敏感的恶性肿瘤,少见于实体肿瘤。笔者发现1例原发性肝癌患者行肝动脉化疗栓塞术(TACE)后出现急性TLS,给予血液透析、保肝及对症支持治疗后,症状好转。

Tumor lysis syndrome (TLS) is the rapid dissolution of tumor cells and cell contents, and its metabolite is rapidly released into the blood, causing a series of complications such as high uric acid, high potassium, high phosphorus,hypocalcemia and acute renal insufficiency. TLS is commonly seen in patients with rapidly growing malignant tumors that are sensitive to chemotherapy, and which is rare in solid tumors. We found one case of primary liver cancer with acute TLS, who was given hemodialysis to protect the liver and symptomatic treatment, and the patient is on the mend.