宫颈癌危险因素探讨

The study on risk factors of cervical cancer

目的探讨本地妇女宫颈癌发生的危险因素。方法选取2013年1月~2016年1月诊治的98例宫颈癌患者为观察组,同时选取236例健康体检者为对照组,对两组患者的宫颈癌发病因素进行对比分析研究。结果经过非条件性单因素及多因素logistic回归分析结果表明:人乳头瘤状病毒(HPV)感染(OR=131.211,P=0.001)、怀孕≥2次(OR=1.218,P=0.012)、初次性交年龄<23岁(OR=0.961,P=0.014)、口服避孕药(OR=1.344,P=0.019)、宫颈糜烂(OR=8.337,P=0.011)是宫颈癌发生的独立危险因素;而文化程度高(OR=6.446,P=0.012)在宫颈癌发生中起保护性作用。结论宫颈癌的预防应当从妇女的生殖健康意识着手,对其开展相应教育,提供保健意识,降低首次性行为年龄、减少避孕药使用及人工流产次数,防治HPV感染及宫颈糜烂。

Objective To investigate risk factors of the local women with cervical cancer.Methods98patients with cervical cancer and236healthy control were collected from January2013to January2016in our hospital.Their healthy physical examination including age,marriage,occupation,cultural degree,contraception was recorded.Results The data were analysed by means of monofactorial and multifactorial conditionallogistic regression model.The result showed that:The infection of HPV(OR=131.211,P=0.001),pregnant more than2times(OR=1.218,P=0.012),age of first sexual intercourse under23years(OR=0.961,P=0.014),oral contraceptives(OR=1.344,P=0.019)of cervical erosion(OR=8.337,P=0.011)are the independent risk factors for cervical cancer;while the high education level(OR=6.446,P=0.012)plays a protective role in the development of cervical cancer.Conclusion To prevention of cervical cancer should be based on women's reproductive health awareness,to carry out the corresponding education,to provide health care awareness,reduce the age of first sexual behavior,reduce the number of abortions,prevention and treatment of HPV infection and the cervical erosion.