420例流产物染色体核型分析

Cytogenetic analysis of miscarriage samples

目的探究流产物染色体异常核型。方法选择420例首次流产(早期流产)患者的宫腔搔刮或负压抽吸的流产物进行染色体核型分析。结果 420例样本染色体核型分析结果正常145例(34.5%),异常230例(54.8%),体外培养未见细胞生长45例(10.7%)。230例染色体异常样本中以染色体数目异常最为常见,主要有16-三体42例(18.2%)、三倍体28例(12.2%)、X单体25例(10.8%)、四倍体12例(5.2%)、15-三体12例(5.2%),其他类型染色体异常包括染色体片段缺失、重复、插入、易位等。结论染色体异常是早期流产的重要原因,其中16-三体是最常见的染色体异常核型。

Objective To examine the chromosome abnormalities in miscarriage samples.Methods Tissue samples were collected from uterine curettage or vocuum suction in420miscarriage patients,and the karyotype analysis was performed.Results There were145cases of normal results(34.5%),230cases of abnormal results(54.8%),and in45samples there was nocell growth(10.7%).In230abnormal samples numerical abnormalities were the most frequent,including16-trisomy(42cases),triploidy(28cases),monosomy X(25cases),tetraploidy(12cases)and15-trisomy(12cases);the other abnormalities were chromosome deletion,duplication,insertion and translocation.Conclusion Cytogenetic alterations are important cause of miscarriages and16-trisomy is the most frequent one.