细胞信号通路影响肝纤维化的研究进展

Research on Progress of the Influence of Cell Signaling Pathway on Hepatic Fibrosis

目的:了解肝纤维化发生、发展过程中细胞信号通路的作用及机制。方法:复习文献,对近年来有关影响肝纤维化细胞信号通路的调控作用及机制进行综述。结果:肝纤维化是慢性肝损害产生的一种肝组织自身病理性修复反应,而转化生长因子-β,血小板衍生生长因子,刺猬信号,Wnt信号,JAK-STAT信号,Notch信号等多条细胞信号通路参与了肝纤维化的发生及发展过程。结论:肝纤维化是刺猬信号、Wnt信号等多条细胞信号通路和一系列细胞信息分子共同作用的结果。

Objective: To investigate the role and mechanism of cell signaling pathway in the occurrence and development of hepatic fibrosis. Methods: The literature about the regulation of cell signaling pathway and its mechanism in recent years were reviewed.Results: Hepatic fibrosis is a pathological repair reaction to the chronic liver damage. Cell signaling pathways like TGF-β, PDGF,hedgehog signaling, Wnt signaling, JAK-STAT and Notch signal participated in the occurrence and development of hepatic fibrosis.Conclusion: Hepatic fibrosis is the result of a series of cell signaling pathways: hedgehog signal, Wnt signal and a series of cell information molecules.