新型抗肿瘤洛铂衍生物LLC-1903的氢谱解析

Explanation of ~1H NMR Spectra of LLC-1903, a New Anticancer Lobaplatin Derivative

测定了新型抗肿瘤洛铂衍生物cis-[trans-1,2-双(氨甲基)环丁烷·3-氧代-1,1-环丁烷二羧酸合铂(Ⅱ)](LLC-1903)在D_2O和DMSO-d_6中的~1H NMR,并进行比较、分析和归属。对2种溶剂中的~1H NMR谱图差异进行了解释,提出在水溶液中由于氢键的形成,导致在环丁烷上的2组CH_2处于不同的空间位置,氢谱出现明显的分裂。

A new derivative of lobaplatin,cis-[trans-1,2-bis(aminomethyl)cyclobutane·3-oxo-1,1-cyclobutanedicarboxylatoplatinum(II)(LLC-1903),was characterized by nuclear magnetic resonancetechnology.1H NMR spectra of the complex both in D2O and DMSO-d6were compared and assigned.The differences of the spectra in D2O and DMSO-d6were explained.It is proposed that the pronouncedspilt observed in D2O for1H peak of CH2groups of3-oxo-1,1-cyclobutanedicarboxylate should becaused by different spatial orientations of the CH2groups in the molecule when the complex is dissolvedin water,and a hydrogen bond ring may be formed by linking H2O with the oxygen of3-carbonyl groupand1-carboxylate together,leading to distortion of the cyclobutane ring.