胃低级别上皮内瘤变内镜下特点及相关因素分析

Endoscopic characteristics and related factors analysis of Low-grade gastric intraepithelial neoplasia

目的分析胃黏膜低级别内瘤变者临床特点、内镜下形态及病理特征,总结其发病特点,以提高其检出率。方法回顾性收集2011年1月1日~2013年12月31日在福建省立医院内镜中心行病理活检首次诊断为低级别内瘤变或轻-中度不典型增生的患者共452例,收集所有患者的临床资料及内镜下特点,其中包括性别、年龄、Hp感染、病变部位、肉眼形态、胃肠化及萎缩情况,分析比较它们之间相互关系,并探讨胃低级别内瘤变合并肠化的危险因素。结果通过logistic回归分析发现年龄、部位、病变形态及Hp感染是导致LGIN合并肠化的危险因素,并具有统计学意义(OR=2.6,9.6、7.5、6.7,16、4.9,3.6,P<0.05)。结论年龄、病变部位、肉眼形态、HP感染是LGIN患者合并肠化的危险因素。

Objective To analyze the clinical features,endoscopic performances and pathological of low-grade gastric intraepithelial neoplasia,and Summarize its clinical features,so as to elevate the detection of gastric low-grade dysplasia.Methods The subjects who pathologically diagnosedwith LGIN for the first time by endoscopy and gastric biopsy in Endoscopy center of Fujian provincial hospital between2011and2013wererecruited,In total,452LGIN lesions were retrospectively studied.all patients were Collected with clinical data and endoscopic features,such as age,gender,endoscopic presentations,location in stomach,infection with Helicobacter pylori,intestinal metaplasia(IM)and gastric atrophy(GA),then analyzedtheir relationships and explored the risk factors of LGIN with IM.Results It was more detected in LGIN with IM and GA,Multivariate analysisindicated that age,location of the lesions,endoscopic presentations and Hp infection were the risk factors of LGIN with IM.Conclusion The age,location of lesions,endoscopic presentations and Hp infection were the risk factors of LGIN with IM.