氧驱动雾化吸入与空气压缩泵雾化吸入治疗小儿哮喘疗效观察及优缺点分析

The observation of therapeutic efficacy of inhalation by oxygen jet nebulizer and air compress pump in treating children asthma and its advantages and disadvantages

目的观察氧驱动雾化吸入与空气压缩泵雾化吸入治疗小儿哮喘的效果及其优缺点。方法 190例小儿支气管哮喘急性发作的患儿被随机平均分为氧驱动雾化吸入(A)组和空气压缩泵雾化吸入(B)组。A组给予布地奈德混悬液0.5 mg+沙丁胺醇0.2 mg+4 m L生理盐水。B组药量与A组相同。观察两组显效率、有效率、总有效率及治疗前后血氧饱和度(SaO_2)和缓解时间。结果 A组总有效率高于B组(95.79%vs 75.79%),失效率低于B组(4.21%vs 24.21%),比较差异有统计学意义(P=0.001)。经雾化治疗后,两组SaO_2水平较治疗前均升高[A:(95.4±0.4)%vs(80.6±0.8)%,B:(92.1±1.1)%vs(79.3±0.7)%](P<0.05),且A组治疗后SaO_2水平高于B组[(95.4±0.4)%vs(92.1±1.1)%](P<0.05)。A组有效缓解和完全缓解时间均高于B组,但差异无统计学意义。结论氧驱动雾化吸入和空气压缩泵雾化吸入均能有效缓解小儿哮喘的临床症状,但氧驱动雾化吸入效果更好,SaO_2水平提高更显著,可作为临床首选方法。

Objective To observe the therapeutic efficacy of inhalation by oxygen jet nebulizer and air compress pump in treating children asthmaand its advantages and disadvantages.Methods190children asthma patients were divided into oxygen jet nebulizer(A)group and air compresspump(B)group.The group A received0.5mg budesonide aerosol and0.2mg Salbutamol with4ml normal sodium were inhaled twice a day by usingoxygen nebulizer,the same in group B by using air compress pump nebulizer.We observed the rate of excellent,efficient,total efficient,arterialoxygen saturation(SaO2)and response duration between the group A and group B.Results The rate of total efficient was significantly higher ingroup A than in group B[(95.79%vs75.79%),P=0.001],but the rate of inefficient was lower[(4.21%vs24.21%),P=0.001].After inhaling treatment,the level of SaO2in group A and B were significantly higher[A:(95.4±0.4vs80.6±0.8),B:(92.1±1.1vs79.3±0.7)](P<0.05),meanwhile there wassignificant difference in the SaO2level between group A and B[(95.4±0.4)%vs(92.1±1.1)%](P<0.05).The effective time and complete responsetime in group A were higher than those in group B,but no significant difference was observed.Conclusion Although both of them were effectivemethods in treating children acute bronchial asthma,compared with air compress pump nebuliser,atomization inhaling by oxygen jet nebulizer couldimprove the treatment effect and oxygen saturation of blood,which presently was the chief method in treating acute children asthma.