哌拉西林钠舒巴坦钠持续静脉滴注治疗重症肺炎的临床研究

Clinical research of piperacillin sodium and sulbactam sodium through continuous intravenous drip in the treatment of severe pneumonia

目的探讨哌拉西林钠舒巴坦钠持续静脉滴注治疗重症肺炎的临床效果。方法 74例重症肺炎患者随机分为观察组与对照组,各37例。对照组采用间断静脉滴注哌拉西林钠舒巴坦钠,观察组采用持续静脉滴注哌拉西林钠舒巴坦钠,比较两组患者的治疗效果、咳嗽消失时间、发热消退时间、机械通气时间、痰液性状改变时间、住院时间、白细胞计数(WBC)及动脉血氧分压(Pa O2)水平。结果观察组治疗总有效率为89.19%,明显高于对照组的70.27%,差异具有统计学意义(P<0.05)。观察组咳嗽消失时间、发热消退时间、机械通气时间、痰液性状改变时间及住院时间明显短于对照组,差异具有统计学意义(P<0.05)。观察组治疗后WBC及Pa O2水平明显优于对照组,差异具有统计学意义(P<0.05)。结论哌拉西林钠舒巴坦钠持续静脉滴注治疗重症肺炎疗效显著,能有效改善症状,缩短治疗时间,具有积极的临床意义,值得推广。

Objective To investigate clinical effect by piperacillin sodium and sulbactam sodium through continuous intravenous drip in the treatment of severe pneumonia. Methods A total of 74 patients with severe pneumonia were randomly divided into observation group and control group, with 37 cases in each group.The control group received piperacillin sodium and sulbactam sodium through intermittent intravenous drip, and the observation group received piperacillin sodium and sulbactam sodium through continuous intravenous drip.Comparison was made on curative effect, cough disappearance time, fever subsidence time, mechanical ventilation time, sputum character changing time, hospital stay time, white blood cell count (WBC) and arterial partial pressure of oxygen (PaO2) levels between the two groups. Results The observation group had obviously higher total effective rate as 89.19% than 70.27% in the control group, and the difference had statistical significance (P<0.05). The observation group had all shorter cough disappearance time, fever subsidence time, mechanical ventilation time, sputum character changing time, and hospital stay time than the control group, and their difference had statistical significance (P<0.05). The observation group had much better WBC and PaO2 levels after treatment than the control group, and the difference had statistical significance (P<0.05). Conclusion Implement of piperacillin sodium and sulbactam sodium through continuous intravenous drip shows excellent curative effect in the treatment of severe pneumonia. This method can effectively improve symptom and shorten treatment time. It contains positive significance, and it is worth promotion.