复治肺结核人群听力损失及耳聋基因筛查的前瞻性研究

Prospective study of hearing loss and deafness gene screening of retreated pulmonary tuberculosis crowd

目的调查复治肺结核人群高频听力下降的程度、发生率以及是否存在相应的耳聋基因突变。方法通过统计475例复治肺结核患者耳聋基因的表达及治疗前、治疗3月后听力情况进行评估。结果复治肺结核患者治疗后平均听阈下降无统计学意义,高频听力同正常对照组比较,差异有统计学意义(P<0.05)。治疗后高频听力下降者33例,mtDNA A1555G突变者8例。结论复治肺结核患者听力损失较多,耳聋基因表达阳性率升高,应当治疗前行常规耳聋基因检测及测试听力,发现听力减退及时治疗。

Objective To investigate the degree of hearing loss and the incidence rate at high frequency of the retreatment pulmonary tuberculosis crowd and whether there was a corresponding deafness gene mutations. Methods Statistical analysis of 475 cases with recurrent pulmonary tuberculosis of deafness gene expression and hearing before and 3 months after treatment were evaluated. Results The average hearing threshold decline of recurrent tuberculosis crowd after treatment had no statistical significance,compared with normal control group,the difference of high-frequency hearing was statistically significant(P<0.05).There were 33 cases in high frequency hearing loss after treatment and 8 cases in mtDNA A1555G gene mutation. Conclusion The retreatment pulmonary tuberculosis patients with hearing loss were more,positive rate of deafness gene expression increased,conventional deafness gene detection and hearing measurement should be given before treatment,if hearing loss is found,timely treatment should be given.