两种抗癫痫药物治疗伴中央颞区棘波的儿童良性癫痫的疗效对比

The efficacy comparison of two antiepileptic drugs for treating benign childhood epilepsy with centro-temporal spikes

目的探讨左乙拉西坦(LEV)与拉莫三嗪(LTG)单药治疗伴中央颞区棘波的儿童良性癫痫(BECTS)患儿对认知功能的影响。方法选取52例BECTS患儿,治疗前及治疗6个月后分别进行智力测试及事件相关电位P300检查,并比较二者结果之间的差异。结果 (1)LEV治疗后P300潜伏期、智力测试与治疗前比较,t=2.327、-6.194,差异有统计学意义(P<0.05);(2)LTG治疗后P300潜伏期、智力测试与治疗前比较,t=4.391、-10.445,差异有统计学意义(P<0.05);(3)LEV与LTG单药治疗后P300潜伏期t=1.392,智力测试t=-1.387,差异无统计学意义(P>0.05)。结论 LEV与LTG均通过有效抑制癫痫样放电,进而改善患儿智力水平,两药之间对比对智力影响差异无统计学意义。

Objective To study of the influence on cognitive function in children with benign childhood epilepsy with centro-temporal spikes(BECTS)monotherapy with levetiracetam(LEV)or lamotrigine(LTG).Method52cases with BECTS,intelligence test and event related potentials(ERPs)P300were examined respectively before treatment and after six months of treatment,and then compared the differences of the results.Results①Compared with before treatment group,ERPs the differences of P300latency and intelligence test were statistically significant then after treatment group of LEV(P<0.05).②Compared with before treatment,the differences of ERPs P300latency and intelligence test were statistically significant then after treatment group of LTG(P<0.05).③After monotherapy of LEV and LTG,P300latency and intelligence test,There were no statistical difference(P>0.05).Conclusion LEV and LTG improved intelligence level of children through supressing epileptiform discharges effectively,there was no difference between the influence of the two drugs on intelligence.