摘要
目的分析急性脑梗死(ACI)患者循环血小板微颗粒(PMP)及内皮细胞微颗粒(EMPs)水平。方法 300例ACI患者分为大面积梗死组72例和小面积梗死组228例,另取健康对照组60例。采集空腹外周静脉血,测定血浆PMP、EMPs及血清心型脂肪酸结合蛋白(H-FABP)、S-100β蛋白(S-100β)、神经元特异性烯醇化酶(NSE)、基质金属蛋白酶原(MMP-9)水平。分析PMP、EMPs与H-FABP、S-100β、NSE、MMP-9的相关性。结果大面积梗死组的血浆PMP和EMPs水平高于小面积脑梗死组,健康对照组最低,差异有统计学意义(P<0.05)。大面积梗死组的血清H-FABP、S-100β、NSE、MMP-9水平高于小面积脑梗死组,对照组最低,差异均有统计学意义(P<0.05)。ACI患者PMP和EMPs水平与H-FABP、S-100β、NSE、MMP-9水平均呈正相关(P<0.05)。结论高水平的PMP及EMPs可能参与了ACI的发生和发展,有望成为疾病诊断、病情评估和预后的新指标。
Objective To study was attempted to evaluate the expression levels of circulating platelet microparticles(PMP)and endothelial microparticles(EMPs)in acute cerebral infarction(ACI)patients.Method A total of300ACI patients have enrolled,including large area ACI group(n=72)and small area ACI group(n=228),meanwhile60healthy persons were selected as the control group.Collection fasting peripheral venousblood and detected the plasma levels of PMP and EMPs and the serum levels of H-FABP,S-100β,NSE,MMP-9.The relationship between PMP,EMPs and H-FABP,S-100β,NSE,MMP-9were observed.Results The plasma levels of PMP,EMPs and the serum levels of H-FABP,S-100β,NSE,MMP-9were all higher in large areaACI group than small area ACI group significantly,moreover,the control group were the lowest(P<0.05).There were positive relationship between levels of PMP,EMPs and levels of H-FABP,S-100β,NSE,MMP-9(P<0.05)Conclusion The high levels of PMP and EMPs may be involved in the development of ACI,which are expected to become new indexes in evaluation of disease,diagnosis and prognosis.
出处
《脑与神经疾病杂志》
2017年第4期242-244,共3页
Journal of Brain and Nervous Diseases
关键词
急性脑梗死
血小板微颗粒
内皮细胞微颗粒
Acute cerebral infarction
Platelet microparticles
Endothelial microparticles