曲美布汀联合多塞平治疗功能性消化不良的临床疗效观察

Observation of clinical effect by trimebutine combined with doxepin in the treatment of functional dyspepsia

目的研究曲美布汀联合多塞平治疗功能性消化不良的方法及临床疗效。方法 122例功能性消化不良患者随机分为观察组和对照组,每组61例。对照组患者单独使用曲美布汀进行治疗,观察组患者使用曲美布汀联合多塞平进行治疗,对比两组患者的治疗效果,以及发生不良反应发生率。结果观察组患者治疗总有效率为93.44%,明显高于对照组的75.41%,差异具有统计学意义(P<0.05)。观察组不良反应发生率为8.20%,明显低于对照组的22.95%,差异具有统计学意义(P<0.05)。结论使用曲美布汀联合多塞平治疗功能性消化不良,能够取得更为理想的临床疗效。

Objective To research method and clinical effect by trimebutine combined with doxepin in the treatment of functional dyspepsia.Methods A total of122patients with functional dyspepsia were randomly divided into observation group and control group,with61cases in each group.The control group received trimebutine alone for treatment,and the observation group received trimebutine combined with doxepin for treatment.Comparison was made on curative effect and incidence of adverse reactions between the two groups.Results The observation group had obviously higher total effective rate in treatment as93.44%than75.41%in the control group,and their difference had statistical significance(P<0.05).The observation group had muchlower incidence of adverse reactions as8.20%than22.95%in the control group,and the difference had statistical significance(P<0.05).Conclusion Implement of trimebutine combined with doxepin in treating functional dyspepsia provides ideal clinical effect.