甲氨蝶呤联合来氟米特治疗类风湿性关节炎的疗效分析

Analysis of curative effect by methotrexate combined with leflunomide in the treatment of rheumatoid arthritis

目的研究和分析甲氨蝶呤与来氟米特联合治疗类风湿性关节炎(RA)的临床疗效。方法 230例类风湿性关节炎患者为研究对象,随机分为对照组和实验组,各115例。实验组患者给予甲氨蝶呤与来氟米特联合治疗,对照组患者仅给予甲氨蝶呤口服治疗,两组患者均治疗24周。观察两组患者临床疗效以及不良反应。结果治疗后实验组患者总有效率为87.83%,明显高于对照组的69.57%,差异具有统计学意义(P<0.05)。两组不良反应情况相似,均表现为恶心呕吐、腹胀、腹泻等消化道症状、口腔溃疡、皮疹、皮肤瘙痒等。两组患者不良反应较轻微,可自行缓解。实验组不良反应发生率为6.09%,与对照组的9.57%比较差异无统计学意义(P>0.05)。结论甲氨蝶呤与来氟米特联合治疗类风湿性关节炎,可明显改善类风湿性关节炎患者的临床症状,具有较好的临床疗效,值得临床治疗中推广应用。

Objective To research and analyze clinical effect by methotrexate combined with leflunomide in the treatment of rheumatoid arthritis(RA).Methods A total of230patients with rheumatoid arthritis as study subjects were randomly divided into control group and experimental group,with115cases in each group.The experimental group received methotrexate combined with leflunomide for treatment,and the control group received oral administration of methotrexate alone for treatment.Treatment in both groups lasted for24weeks.Observation was made on clinical effects and adverse reactions in the two groups.Results The experimental group had obviously higher total effective rate after treatment as87.33%than69.57%in the control group,andthe difference had statistical significance(P<0.05).Both groups showed similar adverse reactions as nausea and vomiting,abdominal distension,diarrhea,oral ulcer,rash and cutaneous pruritus.Adverse reactions in both groups were mild with spontaneous remission.The experimental group had incidence of adverse reactions as6.09%,which was9.57%in the control group,and their difference had no statistical significance(P>0.05).ConclusionCombination of methotrexate and leflunomide in treating rheumatoid arthritis can remarkably improve clinical symptoms in rheumatoid arthritis patients,along with excellent clinical effect.This method is worth promoting and applying in clinical treatment.