雾化吸入布地奈德治疗急性喉炎的临床疗效观察

Observation of clinical effect by budesonide aerosol inhalation in the treatment of acute laryngitis

目的观察雾化吸入布地奈德对急性喉炎临床症状和预后效果的影响。方法 92例急性喉炎患者,根据所用激素的不同分成布地奈德组(49例)和地塞米松组(43例)。布地奈德组采用布地奈德雾化吸入,地塞米松组采用地塞米松静脉给药。对比两组患者临床症状改善时间、临床疗效等级评价结果和药物不良反应差异性。结果布地奈德组喉鸣音平均消失时间为(2.85±0.72)d,声音嘶哑平均消失时间为(3.02±0.65)d,犬吠样咳嗽平均消失时间为(3.94±0.83)d,呼吸困难平均消失时间为(1.39±0.45)d,地塞米松组喉鸣音平均消失时间为(3.67±0.94)d,声音嘶哑平均消失时间为(3.64±0.89)d,犬吠样咳嗽平均消失时间为(5.03±1.02)d,呼吸困难平均消失时间为(2.01±0.62)d,两组比较差异具有统计学意义(P<0.05)。布地奈德组治疗总有效率为95.92%,地塞米松组总有效率为76.74%,两组临床治疗总有效率比较差异具有统计学意义(P<0.05)。两组治疗期间均无严重不良反应发生。结论与传统应用地塞米松雾化吸入治疗相比,急性喉炎接受雾化吸入布地奈德治疗其预后效果、治疗安全性更为理想,可在临床推广。

Objective To observe influence by budesonide aerosol inhalation on clinical symptoms and prognosis of acute laryngitis.Methods A total of92patients with acute laryngitis were divided by different hormone types into budesonide group(49cases)and dexamethasone group(43cases).The budesonide group received budesonide aerosol inhalation,and the dexamethasone group received dexamethasone through intravenous administration.Comparison was made on improvement time of clinical symptoms,evaluation of clinical effect grade and adverse drug reactions between the two groups.Results The budesonide group had mean laryngeal stridor disappearance time as(2.85±0.72)d,mean hoarseness disappearance time as(3.02±0.65)d,mean barking cough disappearance time as(3.94±0.83)d and mean dyspnea disappearance time as(1.39±0.45)d.The dexamethasone group had mean laryngeal stridor disappearance time as(3.67±0.94)d,mean hoarsenessdisappearance time as(3.64±0.89)d,mean barking cough disappearance time as(5.03±1.02)d and meandyspnea disappearance time as(2.01±0.62)d.The difference had statistical significance between the twogroups(P<0.05).The budesonide group had total effective rate in treatment as95.92%,which was76.74%in thedexamethasone group,and their difference of total effective rate in clinical treatment had statistical significance(P<0.05).There was no severe adverse reaction in both groups during treatment.Conclusion Comparing with traditional application of dexamethasone aerosol inhalation for treatment,budesonide aerosol inhalation shows more ideal prognosis effect and curative safety in treating acute laryngitis.So it can be promoted in clinic.