不同时间服用左旋氨氯地平治疗高血压合并心力衰竭的临床效果研究

Study on clinical effect of levamlopine taken at different time in the treatment of hypertension complicated with cardiac failure

目的探讨分析不同时间服用左旋氨氯地平治疗高血压合并心力衰竭的临床效果及价值。方法 180例高血压合并心力衰竭患者,随机分为观察组与对照组,各90例。所有患者均口服左旋氨氯地平片,其中对照组服药时间为每日8:00~9:00,观察组服药时间为每日20:00~21:00,观察跟踪记录2个月比较两组患者治疗效果。结果治疗后,两组患者舒张压(DBP)与收缩压(SBP)均低于治疗前,差异有统计学意义(P<0.05),且治疗后观察组DBP为(62.8±7.8)mm Hg(1 mm Hg=0.133 k Pa)与收缩压SBP(121.6±8.9)mm Hg血压下降值优于对照组的(70.4±9.3)、(128.1±7.9)mm Hg,差异有统计学意义(P<0.05)。两组患者在心房收缩期血流峰值流速(A)与舒张早期减速时间(EDT)比较,差异无统计学意义(P>0.05);观察组在左室舒张早期血流峰值流速(E)为(76.4±31.8)cm/s与舒张早期充盈时间(EDFP)为(0.21±0.01)s显著低于对照组的(63.2±34.5)cm/s、(0.26±0.02)s,差异有统计学意义(P<0.05)。结论在夜间20:00~21:00服用左旋氨氯地平可以达到更好的降压效果,且对左心室损伤较小,夜间服用左旋氨氯地平治疗高血压合并心力衰竭的临床效果显著,值得进一步研究和推广。

Objective To explore and analyze the clinical effect and value of levamlopine taken at different time in the treatment of hypertension complicated with cardiac failure.Methods A total of180hypertension complicated with cardiac failure patients were randomly divided into observation group and control group,with90cases in each group.All patients received oral levamlopine tablets,and the control group had daily meditation time as8:00~9:00,while the observation group had daily meditation time as20:00~21:00.Treatment effect was compared in two groups after2months of observation,track and record.Results After treatment,both groups had lower diastolic blood pressure(DBP)and systolic blood pressure(SBP)than before treatment,and their difference had statistical significance(P<0.05).The the observation group had better DBP as(62.8±7.8)mm Hg(1mm Hg=0.133kPa),SBP as(121.6±8.9)mm Hg after treatment than(70.4±9.3)and(128.1±7.9)mm Hg in the control group.Their difference hadstatistical significance(P<0.05).Both groups had no statistically significant difference in atrial systolic peak diastolicvelocity(A)and early diastolic E-wave deceleration time(EDT)(P>0.05).The observation group had left ventriclediastolic early peak diastolic velocity(E)as(76.4±31.8)cm/s,early diastolic filling period(EDFP)as(0.21±0.01)s,which were obviously lower than(63.2±34.5)cm/s and(0.26±0.02)s in the control group,and their differencehad statistical significance(P<0.05).Conclusion Taking levamlopine20:00~21:00at night can achieve betterantihypertensive effect with less damage to left ventricle.Taking levamlopine at night shows remarkable clinical effectin the treatment of hypertension complicated with cardiac failure,and it is worthy of further research and extension.