不同剂量辛伐他汀治疗冠心病合并高血脂的比较研究

Comparative study of different doses of simvastatin in the treatment of coronary heart disease complicated with hyperlipidemia

目的:探讨不同剂量辛伐他汀治疗冠心病合并高血脂的效果。方法:收治冠心病合并高血脂患者90例,随机分为对照组、观察1组、观察2组,依次使用辛伐他汀剂量10 mg、20 mg及40 mg,比较3组治疗效果。结果:观察1组和观察2组的疗效优于对照组(P<0.05)。观察2组的不良反应发生率高于对照组(P<0.05)。结论:20 mg辛伐他汀能改善治疗效果,如果患者尚可耐受,可将剂量加至40 mg以期改善临床效果。

Objective:To explore the effect of different doses of simvastatin in the treatment of coronary heart disease complicated with hyperlipidemia.Methods:90 patients with coronary heart disease and hyperlipidemia were selected.They were randomly divided into the control group and the observation 1 group and the observation 2 group.They were treated with simvastatin of 10 mg,20 mg and 40 mg.We compared the therapeutic effect of 3 groups.Results:In the observation 1 group and the observation 2 group,the curative effect was better than the control group(P<0.05).In the observation 2 group,the adverse reaction was higher than that of the control group(P<0.05).Conclusion:20 mg simvastatin can improve the therapeutic effect.If patients can be tolerated,the dose may be increased to 40 mg in order to improve the clinical effect.