高龄患者骨科手术中应用丙泊酚与七氟烷对其术后认知功能影响的对比分析

Comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function of elderly patients undergoing orthopedic surgery

目的:探讨应用丙泊酚与七氟烷对高龄患者骨科手术后认知功能的影响。方法:收治高龄骨科手术患者115例,根据麻醉方式不同分为丙泊酚组和七氟烷组,比较两组认知功能和S100β蛋白水平。结果:手术后,丙泊酚组的认知功能评分明显高于七氟烷组(P<0.05)。两组术后S100β蛋白水平均明显改变,丙泊酚组改善程度明显优于七氟烷组(P<0.05)。结论:丙泊酚对高龄患者骨科手术后认知功能的影响较小。

Objective:To explore the effects of propofol and sevoflurane on postoperative cognitive function of elderly patients undergoing orthopedic surgery.Methods:115 elderly patients undergoing orthopedic surgery were selected.According to the different anesthesia methods,they were divided into the propofol group and the sevoflurane group.We compared the cognitive function and S100β protein level of the two groups.Results:After surgery,the cognitive function score of the propofol group was significantly higher than the sevoflurane group(P<0.05).The levels of S100 β protein were significantly changed in the two groups,and the improvement of the propofol group was significantly better than that of the sevoflurane group(P<0.05).Conclusion:The effect of propofol on postoperative cognitive function of elderly patients undergoing orthopedic surgery was small.