复治涂阳肺结核治疗中左氧氟沙星联合抗结核化疗方案的应用价值分析

Application value of levofloxacin combined with anti tuberculosis chemotherapy in the treatment of retreatment smear positive pulmonary tuberculosis

目的:深入分析和探究左氧氟沙星联合抗结核化疗对于复治涂阳肺结核的治疗结果,然后探讨其实际的应用价值。方法:收治复治涂阳肺结核患者70例,然后按照随机分组的方法分为A组35例和B组35例,对A组的患者进行化疗,B组在A组的基础上给予左氧氟沙星,比较两组患者的治疗效果及不良反应发生情况。结果:A组患者显效15例,好转9例,无效11例,总有效率68.57%;B组患者显效21例,好转10例,无效4例,总有效率88.57%;B组患者的总有效率明显高于A组(P<0.05)。A组患者进行治疗后出现恶心呕吐症状的患者4例,出现失眠症状的患者3例,不良反应发生率20.00%;B组恶心呕吐症状1例,失眠1例,不良反应发生率5.17%,明显低于A组(P<0.05)。结论:在复治涂阳肺结核的治疗方面,左氧氟沙星联合抗结核化疗的应用效果良好,通过左氧氟沙星联合抗结核化疗可以有效促进患者的康复,同时在最大程度上防止不良反应的发生。

Objective:To analyze and explore the treatment effect of levofloxacin combined with anti tuberculosis chemotherapy in retreatment of retreatment smear positive pulmonary tuberculosis.Methods:70 patients with retreatment smear positive pulmonary tuberculosis were selected.According to the method of random grouping,70 patients were divided into A group with 35 cases and B group with 35 cases.The patients in the A group were given chemotherapy.The B group was given levofloxacin on the basis of A group.The treatment effects and adverse reactions were compared between the two groups.Results:In A group,15 cases were markedly effective;9 cases were improved;11 cases were ineffective;the total effective rate was 68.57%.In B group,2 cases were markedly effective;10 cases were improved;4 cases were ineffective;the total effective rate was 88.57%.The total effective rate of B group was significantly higher than that of A group(P<0.05).4 cases had nausea and vomiting symptoms after treatment in A group;3 cases had insomnia symptoms;the adverse reaction rate was 20%.1 case had nausea and vomiting symptoms in B group;1 case had insomnia symptom;the adverse reaction rate was 5.17% ,which was significantly lower than that of A group(P<0.05).Conclusion:In the treatment of retreatment smear positive pulmonary tuberculosis,the application effect of levofloxacin combined with anti tuberculosis chemotherapy is very good.The levofloxacin combined with anti tuberculosis chemotherapy can effectively promote the rehabilitation of patients, and prevent the occurrence of adverse reactions to the greatest extent.