维吾尔族、汉族宫颈病变组织中HPV16E6、E7蛋白表达研究

Expression of HPV16E6 and E7 protein in cervical lesions of Uygur and Han nationality

目的:探讨维、汉族宫颈组织中HPV16E6、E7蛋白表达差异以及引起宫颈病变中的作用机制。方法:收集宫颈组织123例,检测HPV-DNA、E6、E7蛋白。结果:维吾尔族、汉族E6、E7蛋白在不同等级宫颈病变中表达率差异具有统计学意义(P<0.005)。维吾尔族不同等级宫颈病变组织HPV阳性率比较差异具有统计学意义(P<0.005)。结论:维、汉族宫颈病变组织中HPV16E6、E7蛋白阳性表达率差异有统计学意义,维吾尔族中随着宫颈病变级别增加,HPV阳性率增加,E6、E7蛋白检测可预测宫颈病变进展及预后。

Objective:To investigate the expression of HPV16E6 and E7 protein in cervical tissues of Uygur and Han nationality,and to explore the mechanism of cervical lesions.Methods:123 cases of cervical tissue were selected,then detected HPV-DNA,E6,E7 protein.Results:The E6,E7 protein expression in different grades of cervical lesions has statistically significant difference between Uygur and Han nationality(P<0.005).In the Uygur nationality,the positive rate of HPV in different levels of cervical lesions was statistically significant(P<0.005).Conclusion:The positive expression rate of HPV16E6 and E7 protein in cervical lesions had significant differences between the Uygur and Han nationality.In addations,the positive rate of HPV increased with the grade of cervical lesions of Uygur increased,and the detection of E6 and E7 protein can predict the progression and prognosis of cervical lesions.