3-70 Down Regulation of Nrf2 Promotes Apoptosis through Nrf2 Mediated Notch Signaling in Non-small Cell Lung Cancer Cells

The nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial regulator of the cellular antioxidant system. Nrf2 is often constitutively activated in non-small-cell lung cancer (NSCLC) cell lines, which promotes cytoprotection against oxidative stress and xenobiotics[1??3].