纳洛酮在一氧化碳中毒急诊抢救中的临床价值研究

Clinical Value of Naloxone in Emergency Treatment of Carbon Monoxide Poisoning

目的:探讨纳洛酮在一氧化碳中毒急诊抢救中的临床价值。方法:选取2015年6月~2016年6月期间,景德镇市第一人民医院进行急诊抢救的40例一氧化碳中毒患者作为研究对象,根据抢救方法的不同,将其分为对照组(n=20)和观察组(n=20),对照组采用常规抢救方法进行治疗,观察组在常规抢救方法的基础上采用纳洛酮进行治疗,观察分析两组患者的临床治疗效果,住院时间,苏醒时间,病情严重程度评分,入院后的死亡率和后遗症的发生率。结果:观察组患者的治疗效果总有效率(95%)高于对照组患者的总有效率(65%),两组患者的治疗效果总有效率具有一定的差异有统计学意义(P<0.05);观察组患者的苏醒时间(1.14±0.32)h明显短于对照组患者的苏醒时间(3.21±0.89)h,两组患者的苏醒时间具有一定的差异有统计学意义(P<0.05);患者在治疗前的病情严重程度评分(5.06±2.45)与对照组患者的病情严重程度评分(4.96±2.24)无较为明显的差异无统计学意义(P>0.05);治疗后观察组患者的病情严重程度评分(0.32±0.25)明显低于对照组的病情严重程度评分(0.89±0.63);两组患者治疗后的病情严重程度评分具有一定的差异有统计学意义(P<0.05);观察组患者的住院时间(11.6±8.5)d和对照组的住院时间(11.3±8.2)d相比无较为明显的差异无统计学意义(P>0.05);另外,观察组患者入院后的死亡率(0%)明显低于对照组患者的入院后的死亡率(20%),后遗症的发生率(5%)也明显低于对照组患者的后遗症的发生率(35%),两组患者入院后的死亡率和后遗症的发生率具有一定的差异有统计学意义(P<0.05)。结论:在常规抢救方法的基础上采用纳洛酮对一氧化碳中毒的患者进行治疗具有较大的意义,可较好地提高患者的治疗效果,缩短患者的苏醒时间,改善患者的病情严重程度,降低患者的入院死亡率和后遗症发生率,最大程度上缓解患者的各种临床症状,为该病患者的治疗工作提供较为科学的临床价值,值得临床上进一步的推广和采用。

Objective:To investigate the clinical value of emergency treatment of poisoning by naloxone in carbon monoxide.Methods:40cases of carbon monoxide poisoning in our hospital from June2015to June2016were divided into control group(n=20)and observation group(n=20).The control group received routine treatment,while the observation group received naloxone treatment.In hospital time,recoverytime,severity score,mortality and sequelae after admission,were compared between two groups of patients.Results:The total effective rate(95%)in the observation group was higher than that of the control group(65%),(P<0.05);the recovery time(1.14+0.32)h in the observationgroup was shorter than that in the control group(3.21+0.89)h,(P<0.05);the disease severity score between two groups showed no significantdifference(P>0.05);the severity score groups of patients after treatment(0.32+0.25)was significantly lower than the control group the severityscore(0.89+0.63);the after effect isignificance the observation group is lower than the control group(P<0.05);hospitalization time between theobservation group patients(11.6+8.5)d and the control group(11.3+8.2)d showed no obvious difference(P>0.05);in addition,the admitted tohospital mortality(0%)was significantly lower in observation group than that of the control group(20%);the incidence of sequelae(5%)wassignificantly lower than that of the patients in the control group(35%)(P<0.05).Conclusion:Use naloxone in the treatment of carbon monoxidepoisoning showed significant curative effect,with shorter the recovery time,reduced hospital mortality and the incidence rate of sequelae,relieved clinical symptoms,thus,it provides more clinical value for the treatment of patients with the disease,and it is worthy of further clinicalpromotion and use.