美沙拉嗪栓给药方式对轻、中度活动期溃疡性直肠炎的临床疗效探讨

Clinical Effect of Mesalazine on Mild to Moderate Ulcerative Proctitis

目的:探讨美沙拉嗪栓给药方式对轻中度活动期溃疡性直肠炎的临床疗效。方法:选取2014年1月到2016年1月在鹰潭市人民医院治疗的70例轻中度活动期溃疡性直肠炎患者,将患者按照给药方式的不同分为甲组和乙组,两组患者均使用美沙拉嗪栓便后纳肛治疗,甲组35例,用药方式为0.5g/次,2次/d;乙组35例,用药方式为1g/次,1次/d。比较两组患者的治疗效果。结果:甲组和乙组患者治疗后疾病活动指数(disease activity index,DAI)各项评分与治疗前相比均有显著降低,差异具有统计学意义(P<0.05)。甲组和乙组患者不良反应发生率分别为14.3%和17.1%,组间比较差异无统计学意义(P>0.05)。结论:轻、中度活动期溃疡性直肠炎患者予以美沙拉嗪栓治疗,0.5g/次、2次/d和1g/次、1次/d的用药方式治疗均可起到良好的效果,安全性较高。

Objective:To explore the effect of different does of mesalazine on mild to moderate ulcerative proctitis.Methods:70patientstreated in our hospital with mild to moderate ulcerative proctitis from January2014to January2016were randomly divided into group A andB.The first35cases in group A were treated with mesalazine at the dosage of0.5g/,2/d;the other35cases in group B were treated with1g/times,1times/d.The effect was compared between two groups of patients.Results:After treatment,DAI score in both group A and group Bwere improved(P<0.05).The incidence of adverse reaction in group A and B group was14.3%and17.1%respectively,with no significantdifference between groups(P>0.05).Conclusion:The treatment with different doses of mesalazine all can get good effect and slight side effect.