内质网应激调节的凋亡信号通路研究进展

A research of signaling pathways about apoptosis by ERS

内质网(ER)是细胞内具有重要功能的细胞器,广泛存在于真核细胞中,是蛋白质折叠、组装的重要场所。当内质网损伤引起内质网应激(ERS)时,细胞就会启动未折叠蛋白反应(UPR),缓解内质网应激对细胞造成的损伤。但持续、剧烈的内质网应激就会诱导细胞发生凋亡,清除受损细胞。内质网应激介导一系列凋亡信号通路,本文主要介绍了这些由内质网应激所介导的凋亡信号通路。

ER is an important organelles in the cell.It is widely found in eukaryotic cells and is an important place for protein folding and assembling.When ERS is caused by damaging ER,the UPR is activated to relieve damage to the cells caused by ERS.But sustained,intensive ERS can induce cell apoptosis and remove damaged cells.The signaling pathways about apoptosis by ERS was introduced.