活血荣络颗粒联合针刺八脉交会穴治疗脑梗死痉挛性瘫痪临床研究

Clinical Study on Huoxue Rongluo Particles Combined with Acupuncture at Eight Confluent Acupoints in Treatment of Spastic Cerebral Infarction Paralysis

目的观察活血荣络颗粒联合针刺八脉交会穴对脑梗死痉挛性瘫痪的临床疗效及对血清谷氨酸(Glu)、天门冬氨酸(Asp)的影响。方法将60例脑梗死痉挛性瘫痪患者随机分为试验组和对照组各30例。2组均予西医基础治疗,试验组加活血荣络颗粒,每日1剂,分2次口服;针刺八脉交会穴,2日1次。15 d为1个疗程,共6个疗程。观察治疗前及治疗半个月、1个月、3个月临床痉挛指数(CSI)评分、中医症状评分,测定血清Glu、Asp水平,观察中医临床疗效。结果治疗半个月、1个月、3个月2组CSI评分、血清Glu、Asp水平、中医症状评分均较治疗前降低(P<0.05,P<0.01)。治疗半个月2组CSI评分比较差异无统计学意义(t=0.329,P=0.743)。治疗1个月、3个月,试验组CSI评分低于对照组(t=-2.636,P=0.024;t=-4.213,P=0.021)。治疗半个月、1个月,血清Glu、Asp水平2组比较差异有统计学意义(P<0.05,P<0.01)。治疗3个月,Glu、Asp水平2组比较差异无统计学意义(P>0.05)。治疗半个月、1个月、3个月,中医症状评分试验组低于对照组(P<0.05)。试验组中医疗效总有效率为86.67%(26/30),对照组为80.00%(24/30),试验组优于对照组(P<0.05)。结论活血荣络颗粒联合针刺八脉交会穴治疗脑梗死痉挛性瘫痪能缓解痉挛程度、改善中医临床症状,其作用机制可能与降低血清兴奋性神经递质有关。

Objective To observe the clinical efficacy of Huoxue Rongluo Particles combined with acupuncture inthe eight confluent points of spastic cerebral in farction paralysis and its effects on Glu and Asp levels of serum.Methods Totally60patients were divided into two groups:the experimental group and the control group.Both groups received basic Western medicine treatment,and the experimental group received Huoxue Rongluo Particles additionally,one dose a day for two times orally taken;Acupuncture was on eight confluent acupoint,every two days.15d is a treatment course,with6courses in total.Clinical spasticity index(CSI)and TCM symptom scores before treatment and the treatment of half month,1month,3months were observed.The levels of Glu and ASP in serum were detected,and TCM clinical efficacy was observed.Results The CSI score,levels of Glu and Asp in serum and TCM symptom scores of the patients after half-month,one-month,and three-month treatment were lower than those before treatment(P<0.05,P<0.01).There was no statistical significance in CSI score after half month treatment between the two groups(t=0.329,P=0.743).The CSI score in the experimental group after one-month and three-month treatment was lower than the control group(t=-2.636,P=0.024;t=-4.213,P=0.021).There was statistical significance in the levels of Glu and Asp between the two groups after half-month and one-month treatment(P<0.05,P<0.01).There was no statistical significance in the levels of Glu and Asp in the two groups after three-monthtreatment(P>0.05).The TCM symptom scores in experimental group was lower than the control group afterhalf-month,one-month and three-month treatment(P<0.05).The total TCM effective rate was86.67%(26/30)inexperimental group,and80.00%(24/30)in the control group,with the experimental group better than the controlgroup(P<0.05).Conclusion Huoxue Rongluo Particles combined with acupuncture eight confluence acupoints in the treatment of spastic cerebral infarction paralyzed patients can relieve spasm degree,improve TCM clinical symptoms,which mechanism may be related to reducing serum excitatory neurotransmitters.