达沙替尼致不良反应文献分析

Literature Analysis of ADR Induced by Dasatinib

目的:分析达沙替尼致不良反应(ADR)的情况,为临床合理用药提供参考。方法:采用文献学计量方法,对国内外公开报道的达沙替尼致ADR病例进行分析、总结。结果:纳入达沙替尼致ADR共63例,患者年龄主要集中在41~60岁;用药1月内出现ADR的例数最多(25.4%);患者主要来源于亚洲国家和地区(53.9%);达沙替尼致ADR累及器官/系统以呼吸系统(40.1%)、消化系统(17.5%)和血液系统(11.7%)为主;主要临床表现为胸腔积液(23例)、肺动脉高压(15例)、呼吸困难(8例)和腹泻(8例)等。结论:在临床使用达沙替尼过程中应重点监测和防治其ADR,避免严重的ADR发生。

OBJECTIVE:To investigate ADR induced by dasatinib,and to provide reference for clinical rational drug use.METHODS:By means of literature metrology method,dasatinib-induced ADR cases domestically and internationally reported were analyzed.RSEULTS:A total of63ADR cases were induced by dasatinib,and the age of patients were mainly41-60years old.The most cases(25.4%)occurred within1month of medication.The patients mainly were from Asian countries and regions(53.9%).Organs/systems involved in dasatinib induced ADRs were mainly respiratory system(40.1%),digestive system(17.5%)and hematologic system(11.7%).Main clinical manifestations were pleural effusion(23cases),pulmonary artery hypertension(15cases),expiratory dyspnea(8cases),diarrhea(8cases),etc.CONCLUSIONS:Daring the use of dasatinib,great importance should be attached to ADR monitoring and prevention so as to avoid serious ADR.