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糠酸氟替卡松鼻用喷雾剂治疗变应性鼻炎的临床研究 被引量:9

Clinical Study on Fluticasone Furoate Nasal Spray in the Treatment of Allergic Rhinitis
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摘要 目的:探讨糠酸氟替卡松鼻用喷雾剂治疗变应性鼻炎(AR)的临床效果及安全性。方法:将2014年1月-2015年12月在我院治疗的AR患者100例采用随机数字表法分为对照组和观察组,各50例。两组患者均给予减充血剂盐酸羟甲唑啉喷雾剂喷鼻。在此基础上,对照组患者给予布地奈德鼻喷雾剂喷鼻,用药第1天每个鼻孔喷1次,第2天每个鼻孔各2次,之后可根据病情适当增加喷鼻次数,但年龄≤14岁的患儿每日用量不超过6喷,年龄>14岁的患者每日用量不超过8喷;观察组患者给予糠酸氟替卡松鼻用喷雾剂喷鼻,年龄≤14岁的患儿每个鼻孔喷1次(qd),年龄>14岁的患者每个鼻孔喷1次(早晚各1次)。两组均持续治疗30 d。比较两组患者治疗前后鼻部症状总评分(TNSS)和眼部症状总评分(TESS),75、150 Pa压力下的鼻腔总阻力值(TNR)与鼻腔最小横截面积(MCA),以及不良反应发生情况。结果:治疗前,两组患者上述指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者的TNSS评分和观察组患者的TESS评分均较治疗前显著下降,且观察组的TESS评分显著低于对照组,差异均有统计学意义(P<0.05),但对照组患者的TESS评分在治疗前后比较,差异无统计学意义(P>0.05);两组患者在75、150 Pa压力下的TNR均显著小于治疗前,且观察组均小于对照组,差异均有统计学意义(P<0.05);两组患者的MCA均显著小于治疗前,但组间比较差异无统计学意义(P>0.05)。观察组患者的不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:糠酸氟替卡松对AR患者鼻部症状的改善效果与布地奈德相当,但对眼部症状及鼻通气功能的改善效果优于布地奈德,且不良反应较少。 OBJECTIVE:To investigate clinical efficacy and safety of Fluticasone furoate nasal spray in the treatment of allergic rhinitis(AR).METHODS:100AR patients in our hospital during Jan.2014-Dec.2015were divided into control group and observation group according to random number table,with50cases in each group.Both groups received decongestant Oxymetazolinehydrochloride spray.Control group was additionally given Budesonide spray,once each nostril on the first day,twice each nostril on the second day,increasing suitably according to disease condition,less than6times a day for patients younger than14years old,less than8times a day for patients older than14years old;observation group was additionally given Fluticasone furoate nasal spray,once each nostril,qd for patients younger than14years old,once each nostril,while morning and night for patients older than14years old.Both groups received treatment for consecutive30d.The total nasal symptoms score(TNSS),total eye symptoms score(TESS),total nasal resistance(TNR)under75,150Pa,nasal minimum cross-sectional area(MCA)and the occurrence of ADR were compared between2groups before and after treatment.RESULTS:There was no statistical significance in above indexes between2groups before treatment(P>0.05).After treatment,TNSS of2groups and TESS of observation group were decreased significantly compared to before treatment,and TESS of observation group was significantly lower than that of control group,with statistical significance(P<0.05).There was no statistical significance in TESS of control group before and after treatment(P>0.05).TNR of2groups under75,150Pa were significantly lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).MCA of2groups were significantly lower than before treatment,without statistical significance between2groups(P>0.05).The incidence of ADR in observation group was significantly lower than control group,with statistical significance(P<0.05).CONCLUSIONS:Fluticasone furoate is similar to budesonide in the treatment of nasal symptoms of AR patients,but it is better than budesonide in improving eye symptoms and nasal ventilation function with milder ADR.
作者 杨琛 魏鑫鑫 尹中普 YANG Chen;WEI Xinxin;YIN Zhongpu(Nanyang Central Hospital,Henan Nanyang 473000,China)
机构地区 南阳市中心医院
出处 《中国药房》 CAS 北大核心 2017年第11期1503-1506,共4页 China Pharmacy
关键词 变应性鼻炎 糠酸氟替卡松 布地奈德 鼻通气功能 Allergic rhinitis Fluticasone furoate Budesonide Nasal ventilation function
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