氨酚羟考酮在腰椎后路融合术后的镇痛效果观察

Analgesic Efficacy Observation of Oxycodone Acetaminophen after Posterior Lumbar Fusion

目的:观察氨酚羟考酮在腰椎后路融合术后的镇痛效果,优选脊柱术后镇痛方案。方法:采用回顾性研究方法,选择湖北医药学院附属人民医院2013年6月-2014年6月收治的120例腰椎后路融合术患者资料,按治疗方案不同分为观察组和对照组,各60例。观察组患者在术后6 h口服氨酚羟考酮330 mg;术后第1、2天口服氨酚羟考酮330 mg,tid。对照组患者在术后6 h口服塞来昔布200 mg;术后第1、2天口服塞来昔布200 mg,bid。观察术后两组患者静息状态和活动状态下的镇痛效果[视觉模拟评分法(VAS)评分]、术后胃肠运动功能恢复情况(肛门排气时间)和不良反应发生情况。结果:无论是在静息状态下还是在活动状态下,观察组患者术后24、48、72、120 h的VAS评分均显著低于对照组,差异均有统计学意义(P<0.05)。两组患者的肛门排气时间和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:口服氨酚羟考酮对解除脊柱术后疼痛具有较好的效果,且镇痛快速、安全。

OBJECTIVE:To observe analgesic efficacy of oxycodone acetaminophen after posterior lumbar fusion,and to optimize spinal postoperative analgesia plan.METHODS:In retrospective study,120patients underwent posterior lumbar fusion were selected from the Affiliated People’s Hospital of Hubei Medical College during Jun.2013-Jun.2014,and then divided into observation group and control group according to therapy plan,with60cases in each group.Observation group was given oxycodone acetaminophen330mg orally6h after surgery,and then330mg orally on1st,2nd day after surgery,tid.Control group was given celecoxib200mg6h after surgery,and then200mg on1st,2nd day after surgery,bid.Postoperative analgesic efficacy(VASscore)at resting state and active state,postoperative gastrointestinal motility recovery(the time to flatus)and the occurrence of ADR were observed in2groups after surgery.RESULTS:Whether at the resting state or the active state24,48,72,120h aftersurgery,VAS score of observation group was significantly lower than that of control group,with statistical significance(P<0.05).There was no statistical significance in the time to flatus and the incidence of ADR between2groups(P>0.05).CONCLUSIONS:Oral administration of oxycodone acetaminophen possesses good effect to relieve spinal postoperative pain,showing fast and safe analgesic efficacy.