白内障患者术后联用激素和非甾体抗炎药的临床效果考察

Study of the clinical effect about the combination of the drugs hormonal and nonstemidal anti-imqammatory for patients with cataract after operation

目的研究白内障患者术后应用激素联合非甾体抗炎药治疗的临床效果。方法将200例白内障患者随机分为观察组(妥布霉素地塞米松+普拉洛芬)和对照组(妥布霉素地塞米松),每组100例,观察记录患者围治疗期的各项症状和体征的评分及综合评分。结果观察组黄斑囊样水肿发生率和前房闪辉评分明显小于对照组,差异有统计学意义(P<0.05),尽管观察组患者的眼压评分小于对照组,差异无统计学意义;此外在术后4 d和7 d时[(7.1±0.8)vs(8.3±0.9),(5.2±0.9)vs(6.6±0.7)],观察组综合评分显著低于对照组,差异具有统计学意义(P<0.05),而在术后14 d和30 d时[(3.2±0.7)vs(3.3±0.8),(1.1±0.5)vs(1.1±0.6)],差异无统计学意义。结论白内障患者术后联用妥布霉素地塞米松和普拉洛芬可以有效地起到早期抗炎和缓解术后不良反应的作用,具有良好的临床应用价值。

Objective To explore the clinical effect about the combination of the drugs hormonal and nonstemidal anti-imqammatory for patientswith cataract after operation.Methods Two hundred patients with cataract received operation were divided randomly into the observation groupwhich employed the combination of the drugs tobramycin dexamethasone and pranoprofen and the control group which employed tobramycin dexamethasone.Each group was containing100patients.The scores of every symptom,physical sign and general should be statistical record.ResultsAmong two hundred patients with cataract received operation,it is with significantly difference on the cystoid macular edema incidence rate and anteriorchamber flare scores between the observation group and the control group,besides,the former numerical value is less than the latter(P<0.05).There is no significantly difference on the intraocular pressure scores between the observation group and the control group although the former numericalvalue is also less than the latter.In additon,it is with significantly difference on the general scores between the observation group and the controlgroup,besides,the former numerical value is less than the latter after four days and seven days for the operation[(6.3±3.1)vs(9.9±3.5),(6.4±2.7)vs(8.5±3.1)](P<0.05).There is no significantly difference on the general scores between the observation group and the control group althoughthe former numerical value is also less than the latter after fourteen days and thirty days for the operation[(5.6±2.4)vs(8.1±2.5),(5.5±2.3)vs(6.5±2.1)].Conclusion It is effective and valuable to resist inflammatory and adverse reaction with the combination of the drugs tobramycin dexamethasoneand pranoprofen for patients with cataract after operation.