探究静脉注射丙种球蛋白对ABO溶血病患儿血清免疫球蛋白的影响

Exploration of impact of intravenous injection of immunoglobulin on serum immunoglobulin of ABO haemolytic disease children

目的对静脉注射丙种球蛋白在ABO溶血病患儿疾病治疗中的效果及其对血清免疫球蛋白的影响进行分析。方法 110例ABO溶血病患儿作为观察对象,按就诊前后顺序分为研究组与参照组,每组55例。参照组采取常规治疗,研究组在常规治疗基础上予以静脉注射丙种球蛋白治疗。比较两组患儿的血清胆红素水平及其血清免疫球蛋白改变情况。结果治疗前两组患儿血清胆红素水平比较差异无统计学意义(P>0.05);两组患儿治疗24、48、72 h的血清胆红素水平均低于本组治疗前,差异均具有统计学意义(P<0.05);研究组患儿治疗后24、48、72 h的血清胆红素水平低于参照组,差异均具有统计学意义(P<0.05)。两组治疗前及治疗8周免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)比较差异均无统计学意义(P>0.05);研究组治疗2 d IgG、IgM(13.26±3.41)、(0.30±0.19)g/L与参照组(8.94±1.58)、(0.42±0.20)g/L比较差异均具有统计学意义(P<0.05);研究组治疗4周IgA(0.20±0.14)g/L与参照组(0.37±0.19)g/L比较差异具有统计学意义(P<0.05)。结论对ABO溶血病患儿采取丙种球蛋白静脉注射治疗,疗效显著,可有效控制血清胆红素与免疫球蛋白水平,值得在临床上大力推广。

Objective To analyze the effect of intravenous injection of immunoglobulin in the treatment of ABO haemolytic disease children,and its impact on serum immunoglobulin.Methods A total of110ABO haemolytic disease children as observation subjects were divided by visiting sequence into research group and control group,with55cases in each group.The control group received conventional therapy,and the research group received intravenous injection of immunoglobulin on the basis of conventional therapy.Comparison were made on serum bilirubin level and serum immunoglobulin changes in two groups.Results Before treatment,both groups had no statistically significant difference in serum bilirubin level(P>0.05).Both groups had lower serum bilirubin level after24,48and72h of treatment than before treatment,and the difference had statistical significance(P<0.05).The research group had lower serum bilirubin level after24,48and72h of treatmentthan the control group,and the difference had statistical significance(P<0.05).Both groups had no statisticallysignificant difference in immune globulin A(IgA),immune globulin G(IgG)and immune globulin M(IgM)before treatment and after8weeks of treatment(P>0.05).The research group had statistically significant difference inIgG and IgM respectively as(13.26±3.41)and(0.30±0.19)g/L after2d of treatment comparing with(8.94±1.58)and(0.42±0.20)g/L in the control group(P<0.05).The research group had statistically significant difference inIgA as(0.20±0.14)g/L after4weeks of treatment comparing with(0.37±0.19)g/L in the control group(P<0.05).Conclusion Intravenous injection of immunoglobulin on serum immunoglobulin shows significant curative effectfor ABO haemolytic disease children,and it can effectively control serum bilirubin and serum immunoglobulin level.So it is worth promoting in clinic.