利培酮治疗精神分裂症患者所致泌乳素升高与骨密度下降的相关性研究

Risperidone in the treatment of schizophrenia patients caused by the correlation between prolactin rise and bone research

目的探讨利培酮治疗精神分裂症患者所致泌乳素升高与骨密度下降的相关性。方法选择住院的25~45岁年龄段的精神分裂症患者100例,首发病例50例为对照组,住院接受利培酮单药维持治疗的病例50例为实验组,给予对照组常规药物治疗,给予观察组利培酮药物治疗。结果对照组治疗3周后的泌乳素为(25.31±14.52),实验组治疗3周后的泌乳素为(75.23±51.28),两组对比差异具有统计学意义(P<0.05)。实验组治疗后腰椎1的骨密度为(0.95±0.16),对照组腰椎1的骨密度为(1.15±0.18),两组对比差异具有统计学意义(P<0.05)。结论利培酮治疗精神分裂症患者,随着剂量的增加,患者利培酮血药浓度升高,同时引起患者泌乳素升高和骨密度下降的现象,由此增加患者骨折的风险,因此要谨慎的使用抗精神病药物。

objective To explore risperidone in the treatment of schizophrenia patients caused by the correlation between prolactin rise and bone loss.Methods Select25-5years of age in hospital,100cases of patients with schizophrenia,the initial cases50cases as control group,hospital to risperidone single drug maintenance treatment of50cases of experimental group,give control group routine drug treatment,given risperidone therapy,observation group.The results of the control group after treatment for3weeks prolactin(25.31±14.52),the experimental group after3weeks of treatment prolactin(75.23±51.28),compared the two groups statistically significant difference(P<0.05).The experimental group after the treatment of lumbar spine1bone mineral density(0.95±0.16),the control group lumbar spine bone mineral density of1(1.15±0.18),compared the twogroups statistically significant difference(P<0.05).Conclusion Risperidone in the treatment of schizophrenia patients,along with the increase ofthe dose risperidone in patients with elevated blood drug concentration,meanwhile prolactin rise and cause of reduced bone mineral density,thus in creasethe risk of patients with fracture,so be careful use of antipsychotic drugs.