佳木斯地区6岁以下儿童血清维生素A、25-羟基维生素D、维生素E水平分析

Levels of serum vitamin A,25-hydroxyvitamin D and vitamin E of children under 6 years old in Jiamusi

目的了解黑龙江佳木斯地区6岁以下儿童血清维生素A(Vit A)、25-羟基维生素D[25(OH)D]、维生素E(Vit E)水平,为临床高危年龄段人群合理补充Vit A、维生素(Vit D)、Vit E及预防相关疾病的发生提供参考。方法将5 169名6岁以下儿童按年龄分为<1岁组(732名)、1~岁组(831名)、2~岁组(693名)、3~岁组(1 164名)、4~岁组(1 008名)、5~岁组(741名)。完成问卷调查,抽取静脉血,采用高效液相色谱法检测血清Vit A、Vit E水平,采用高效液相色谱串联质谱法检测血清25(OH)D水平。结果 5 169名6岁以下儿童血清Vit A水平为(0.28±0.087)mg/L、不足率为54.09%、缺乏率为13.46%,不同年龄段血清Vit A水平差异有统计学意义(F=4.370,P=0.001),其中<1岁组血清Vit A水平最低[(0.25±0.071)mg/L],不足率为61.48%、缺乏率为19.67%。血清25(OH)D水平为(24.20±9.97)ng/mL,不足率为18.57%、缺乏率为17.99%;随着年龄的增大,血清25(OH)D水平逐渐降低。血清Vit E平均水平为(8.68±2.49)mg/L,不足率为21.53%,缺乏率为0.58%,随着年龄的增大,血清Vit E水平呈减低趋势。结论佳木斯地区6岁以下儿童Vit A、25(OH)D水平不容乐观,需要针对高危年龄段人群及时检测、合理补充,以预防维生素缺乏症的发生,而Vit E营养状况相对良好。

Objective To investigate the levels of serum vitamin A(Vit A),25-hydroxyvitamin D[25(OH)D]and vitamin E(Vit E)of children under6years old in Jiamusi,and to provide a reference for the reasonable supplementation of Vit A,vitamin D(Vit D)and Vit E and preventing from related diseases.Methods According to ages,5169children were classified into6groups,<1-year-old group(732cases),1-year-old group(831cases),2-year-old group(693cases),3-year-old group(1164cases),4-year-old group(1008cases)and5-year-old group(741cases).After achieving questionnaires,the venous blood was extracted.The levels of Vit A and Vit E were determined by high-performance liquid chromatography,and the level of25(OH)D was determined by high-performance liquid chromatography tandem mass spectrometry.Results The level of Vit A was(0.28±0.087)mg/L.The insufficiency rate was54.09%,and the deficiency rate was13.46%.There was statistical significance with different ages(F=4.370,P=0.001).The minimal level of Vit A was(0.25±0.071)mg/L in<1-year-old group,the insufficiency rate was61.48%,and the deficiency rate was19.67%.The level of25(OH)D was(24.20±9.97)ng/mL,the insufficiency rate was18.57%,and the deficiency rate was17.99%.With the increasing of ages,the levels of25(OH)Ddecreased.The average level of Vit E was(8.68±2.49)mg/L,the insufficiency rate was21.53%,and the deficiency rate was0.58%.With the increasing of ages,the level of Vit E had a decreasing tendency.Conclusions The nutritional status of Vit A and25(OH)D of children under6years old is not optimistic in Jiamusi.It is necessary to determine and give reasonable supplementation of vitamin for high-risk subjects in order to prevent from vitamin deficiency disorder.The nutritional status of Vit E is relatively good.