食物不耐受检测在复发性阿弗他溃疡中的临床价值

Food intolerance testing for recurrent aphthous ulcer

目的探讨食物不耐受检测在复发性阿弗他溃疡(RAU)治疗与预防中的临床价值。方法使用酶联免疫吸附试验检测410例RAU患者和120名健康体检者(正常对照组)血清中14种食物不耐受特异性IgG抗体。结果 410例RAU患者中有350例(85.37%)食物不耐受特异性IgG抗体阳性,明显高于正常对照组(28.33%,P<0.01),且多种食物不耐受特异性IgG抗体阳性率明显增高(P<0.01)。RAU组中蛋清/蛋黄抗体的阳性率及抗体水平均为最高,各种食物不耐受特异性IgG抗体水平均明显高于正常对照组(P<0.01)。RAU组牛肉、虾、鸡肉、猪肉不耐受程度均以轻度为主,抗体阳性率与正常对照组比较差异无统计学意义(P>0.05),但抗体水平明显高于正常对照组(P<0.01)。RAU组中食物不耐受特异性IgG抗体阳性者的抗体水平明显高于抗体阴性者(P<0.01),而抗体阴性者明显高于正常对照组(P<0.01)。对RAU患者给予相应食物控制后,随访3个月,63.55%(258/406)的患者溃疡症状得到有效缓解。结论 RAU与食物不耐受密切相关,发现并限制接触不耐受食物有助于RAU的治疗与预防。

Objective To investigate food intolerance testing for the treatment and prevention of recurrentaphthous ulcer(RAU).Methods Serum samples of410patients with RAU and120healthy subjects(healthcontrol group)were collected.Serum food-specific immunoglobulin(Ig)G antibodies against14foods were determined by enzyme-linked immunosorbent assay.Results A total of350cases in RAU group(85.37%)were determined food-specific IgG antibodies positive,and the positive rate was higher than that in healthy control group(28.33%,P<0.01).Furthermore,the positive rate of multiple food intolerance in RAU group was higher than that in healthy control group(P<0.01).In RAU group,the positive rate and level of egg-specific IgG antibody were the highest.The levels of food-specific IgG antibodies in RAU group were higher than those in healthy control group(P<0.01).RAU group showed a mild intolerance to beef,shrimp,chicken and pork,and the positive rates of food-specific IgG antibodies against them had no statistical significance between RAU and healthy control groups(P>0.05),while the levels of food-specific IgG antibodies in RAU group were higher than those in healthy control group(P<0.01).The food-specific IgG antibody level of IgG positive in RAU group was higher than that of IgG negative in RAU group(P<0.01),and the food-specific IgG antibody level of IgG negative in RAU group was higher than that in healthy control group(P<0.01).After a3-month follow-up of RAU group,a modification of dietary brought an effective relief to ulcer in258of406cases(63.55%).Conclusions There is a close relationship between food intolerance and RAU,and the identification of intolerable foods and avoiding consumption of them are of value in clinical treatment and prevention of RAU.