消风蠲痹汤治疗急性痛风性关节炎的临床研究

A clinical study on treating gouty arthritis with the Xiaofeng Juanbi decoction

目的:观察消风蠲痹汤治疗痛风性关节炎的临床疗效和安全性。选取2015年8月-2016年8月广东省中西医结合医院肾病风湿科60例急性痛风性关节炎(湿热内蕴证型)患者,随机分为两组,消风蠲痹汤治疗组30例(观察组);口服秋水仙碱及碳酸氢钠片治疗组30例(对照组);疗程均为1周。治疗结束后观察患者临床疗效及各项化验指标改善情况,并观察两组治疗过程中出现的不良反应。结果:(1)观察组和对照组总有效率分别为93.3%和90.0%,两组疗效差异无统计学意义(P>0.05);(2)观察组中医证候积分的改善优于对照组,治疗后其积分明显低于对照组(P<0.01);(3)两组治疗后血尿酸、C反应蛋白、白细胞计数等实验室指标与本组治疗前相比均下降,尿p H值较前升高,差异有统计学意义(P<0.01);两组治疗后比较,观察组血尿酸水平下降程度优于对照组,差异有统计学意义(P<0.05);其余各项化验指标比较差异无统计学意义。对照组的不良反应发生例次为6例,观察组为3例,两组比较差异无统计学意义。结论:消风蠲痹汤治疗急性痛风性关节炎的综合疗效优于秋水仙碱、碳酸氢钠合用,且治疗过程中不良反应较少,具有较好的临床应用前景。

Objective:To observe the clinical effect and safety of the Xiaofeng Juanbi decoction on gouty arthritis.Methods:From August2015to August2016,60cases were divided into the observed group and control group,30cases in each group.The observed group was given the Xiaofeng Juanbi decoction;and the control group took colchicine tablets and sodium bicarbonate tablets,for1week.Results:In7days,the total efficiency was93.3%in the observed group,and90.0%in the control group(P>0.05).TCM syndrome was more decreased in the observed group(P<0.01).After treatment,indexes of BUA,CRP and WBC were more decreased,pH of the urine was more increased in both groups,and those in the observed group were better(P<0.01).After treatment,BUA in the observed group was more decreased(P<0.05).The incidence of adverse reaction in the observation group(3cases)was fewer than6cases in the control group(P>0.05).Conclusion:The Xiaofeng Juanbi decoction is more effective on gouty arthritis,with fewer adverse reactions,and is worthy of application.