小剂量阿司匹林治疗老年冠心病患者的远期疗效分析

Long-term Efficacy of Low-dose Aspirin on Senile Patients with Coronary Heart Disease

目的:研究小剂量阿司匹林治疗老年冠心病患者的远期疗效分析。方法:分析我院在2014年1月~2015年2月收治的老年冠心病患者90例的临床资料,按治疗方案将患者分为两组(每组45例),观察组予以阿司匹林50mg/d,对照组予以阿司匹林100mg/d,观察两组患者的治疗疗效及血脂水平、血小板聚集功能、随访1年后两组患者的复发情况。结果:两组患者治疗后观察组的总有效率(97.8%)明显高于对照组(84.4%)(P<0.05);治疗前两组患者血脂各项指标比较,无差异(P>0.05);两组患者治疗后与同组治疗前比较,血脂各项指标明显好转(P<0.05);治疗后观察组血脂各项指标与对照组比较无差异(P>0.05);两组患者在治疗前血小板聚集功能比较,无差异(P>0.05);治疗后两组患者血小板聚集功能比较,观察组明显优于对照组(P<0.05),与同组治疗前比较血小板聚集功能下降(P<0.05);随访1年后,两组患者复发情况差异无统计学意义(P>0.05);治疗过程中两组患者未出现明显不良反应。结论:小剂量阿司匹林治疗老年冠心病患者可有效的控制患者的病情,且无明显不良反应,值得在临床上大力推广。

Objective:To study the long-term efficacy of low-dose aspirin on senile patients with coronary heart disease(CHD).Methods:In total,90senile patients with coronary heart disease were admitted and treated in the Second People’s Hospital of Jiaozuo from January2014to February2015.They were divided into control group and test group with45patients in each group.Patients in test group were given aspirin50mg/d,while patients in control group were given aspirin100mg/d.Then the efficacy,lipid levels,platelet aggregation,and relapse rates after one year between two groups were observed.Results:(1)After treatment,the total effective rate of the test group(97.8%)were significantly higher than that of control group(84.4%)(P<0.05).(2)Before and after treatment,there was no significant difference in blood lipids between two groups(P>0.05).However,the blood lipids in two groups were significant improved after treatment,comparing with the same group before treatment(P<0.05).After treatment,there was no significant difference in two groups(P>0.05).(3)Before treatment,in two groups,there was no significant difference in platelet aggregation function(P>0.05),fortunately,it was significant in test group better than that in control group after treatment.However,It was decreased significantly in two groups comparing with the same group before treatment(P<0.05).(4)After1year follow-up,there was no significant difference in the relapse of coronary heart disease between two groups.(5)No obvious adverse events were found during the period of treatment(P>0.05).Conclusions:The rational use of low-dose aspirin in the treatment of senile cardiovascular heart diseases can effectively control the symptoms and less adverse,is worthy of clinical application.