摘要
Previous studies in malignant cells have shown that irradiation-induced upregulation of telomerase activity,not only protected damaged telomeres, but also contributed to DNA damage repair by chromosomal healing andincreased resistance to irradiation[1;2].To investigate the radiosensitizing mechanism of telomerase inhibition, the influence of telomerase inhibitor(MST-312) combined with X-ray irradiation on -H2AX foci were determined. As shown in Fig. 1(a), the combinedtreatment resulted in retention of -H2AX nuclear foci and significant decrease of DNA damage repair.
基金
Key Program of National Natural Science Foundation of China (U1432248), Western Talent Program of ChineseAcademy of Sciences (Y460040XB0), National Natural Science Foundation of China (11175222).
