鼻咽癌中MACC-1的表达与临床病理特征和预后间的关系

The relationship between MACC-1 expression and clinical pathologic characteristics, prognosis in nasopharyngeal carcinoma

目的探讨MACC-1在鼻咽癌肿瘤组织中的表达情况及与鼻咽癌临床病理特征和预后的关系。方法选取我院2006年1月~2012年12月确诊并行放射治疗的鼻咽癌患者肿瘤组织90例及同期送检的慢性炎症鼻咽黏膜组织标本75例,采用免疫组化S-P法检测MACC-1在鼻咽癌组织中和慢性炎症组织中的表达情况,分析鼻咽癌组织中MACC-1表达与临床病理特征和预后的关系。结果鼻咽癌肿瘤组织中MACC-1的免疫组化评分及表达阳性率高于慢性炎症组织,差异具有统计学意义(P<0.05);T_3~T_4期患者MACC-1表达阳性率高于T_1~T_2期患者,差异具有统计学意义(P<0.05);N_(1~3)期患者的阳性率高于N_0期患者,差异具有统计学意义(P<0.05);临床分期中Ⅲ~Ⅳ期患者MACC-1阳性率显著高于Ⅰ~Ⅱ期患者,差异具有统计学意义(P<0.05)。MACC-1表达阳性患者生存率(50.8%)低于MACC-1表达阴性患者(77.8%),差异具有统计学意义(χ~2=8.094,P<0.05)。结论 MACC-1的高表达与鼻咽癌中高TN分期和临床分期具有相关性,且与放疗后患者生存期具有相关性,是预测鼻咽癌患者预后的独立危险因素。

Objective To research the expression of metastasis-associated in colon cancer-1in the patients with nasopharyngeal carcinoma,and its relationship with clinical pathologic characteristics and prognosis.Methods90patients with NPC and75patients with chronic rhinitis in our hospital from Jan2006to Dec2012were selected.The expression of MACC-1was detected in all the patients.The relationship between the MACC-1expression and clinical pathologic characteristics,prognosis of NPC was analyzed.Results Positive expression rate of MACC-1in the NPC group was higher than the chronic rhinitis group,and the difference between the two groups was statistically significant(P<0.05).Positive expression rate of MACC-1in the T3~T4stage patients was significantly higher than the T1~T2stage patients(P<0.05).Positive expression rate of N1~3stage patients was significantly higher than the N0stage patients(P<0.05).Positive expression rate of MACC-1in theⅢ~Ⅳstage patients was significantly higher than theⅠ~Ⅱstage patients(P<0.05).The overall survival rate in patients with positive expression was significantly lower than patients with negative expression(P<0.05).Conclusion The positive expression of MACC-1is closely related to the TN stages,clinical stages and the overall survival.And MACC-1is an independent prognostic factor for NPC.