初诊2型糖尿病患者补充维生素D3与胰岛素抵抗的相关性研究

Study on the relationship between Vitamin D3 supplementation and insulin resistance in newly diagnosed patients with type 2 diabetes

目的观察伴有维生素D缺乏的初诊2型糖尿病患者,补充维生素D3后胰岛素抵抗及相关指标的变化。方法将伴有维生素D缺乏的初诊2型糖尿病患者120例,随机分成3组,对照组常规治疗,实验组A和实验组B在常规治疗基础上分别予以维生素D3 1 000U/d和2 000U/d,12周后观察25-羟维生素D、糖化血红蛋白、血糖、胰岛素、钙、磷、甲状旁腺激素的变化。结果 25-羟维生素D在治疗前后实验组A及实验组B差异均有统计学意义(P<0.05),HOMAIR、血糖、PTH在实验组B中治疗前后及与对照组之间的差异均有统计学意义(P<0.05)。结论通过补充较大剂量的维生素D3可使血糖下降、HOMA-IR改善。

Objective To investigate the changes of insulin resistance and related indexes after Vitamin D3supplementation in newly diagnosed patients with type2diabetes accompanied with Vitamin D deficiency.Methods120newly diagnosed patients with type2diabetes accompanied with Vitamin D deficiency were randomly divided into three groups.The control group was treated with routine therapy.The experimental group A and the experimental group B were treated with Vitamin D31000U/d and2000U/d based on routine therapy.After12weeks,observed the changes of25-hydroxy Vitamin D,glycosylated hemoglobin,blood glucose,insulin,calcium,phosphorus,parathyroid hormone.Results There was statistical significance in the level of25-hydroxy Vitamin D between the experimental group A and the experimental group B before and after the treatment(P<0.05),and there were also statistical significances in the levels of HOMA-IR,blood glucose and PTH between the two groups before and after the treatment(P<0.05).Conclusion Supplementation of higher doses of Vitamin D3can lower blood glucose and improve HOMA-IR.