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布鲁氏菌病活疫苗(M5株)和口蹄疫灭活疫苗同时免疫绵羊的试验 被引量:2

Immune Responses in Sheep after Simultaneous Immunization with Brucellosis Live Vaccine (M5) and Foot and Mouth Disease Inactivated Vaccine
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摘要 为研究布鲁氏菌病活疫苗(M5株)和口蹄疫灭活疫苗同时免疫绵羊后的效果,选择50只育肥羊,分别用布鲁氏菌病活疫苗(M5株)和口蹄疫O型、亚洲Ⅰ型二价灭活苗,同时对绵羊进行注射免疫,30 d后采血检测免疫抗体。结果表明:布鲁氏菌病虎红平板凝集抗体阳性率达100%,且均呈强阳性反应;O型和亚洲Ⅰ型口蹄疫抗体合格率分别达78%和80%。试验结果初步证明,布鲁氏菌病活疫苗(M5株)和口蹄疫O型、亚洲Ⅰ型二价灭活疫苗同时对绵羊进行免疫,同样可以达到预期的免疫效果。 In order to investigate the immune responses in sheep after simultaneous vaccination with Brucellosis live vaccine and Foot and mouth disease(FMD)inactivated vaccine,50fattening sheep were immunized with both the Brucellosis live vaccine(strain M5)and FMD divalent vaccine(type O and Asia I).30days after immunization,the post-vaccination antibodies of the sheep were detected.Results showed that the positive rate of antibodies against Brucellosis was100%according to the Rose Bengal plate agglutination test,indicating a strong positive reaction.In addition,the qualification rates of antibodies against FMD of type O and Asia I were78%and80%,respectively.As a conclusion,these preliminary results demonstrated that a desired immune effect could be achieved by simultaneously immunizing sheep with Brucellosis live vaccine(strain M5)and FMD divalent vaccine(type O and Asia1).
作者 何彦春 曹丽萍 李生静 张瑜 He Yanchun;Cao Liping;Li Shengjing;Zhang Yu(Zhangye Animal Disease Prevention and Control Center,Zhangye,Gansu 734000;Gansu Animal Disease Prevention and Control Center;Lanzhou,Gansu 730000;Linze Animal Disease Prevention and Control Center,Linze,Gansu 734200)
出处 《中国动物检疫》 CAS 2017年第5期99-100,105,共3页 China Animal Health Inspection
关键词 布鲁氏菌病 口蹄疫 免疫效果 绵羊 Brucellosis Foot and mouth disease immune effect sheep
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