高渗盐水联合布地奈德雾化吸入治疗毛细支气管炎临床研究

Clinical study of hypertonic saline combined with budesonide aerosol inhalation in the treatment of capillary bronchitis

目的研究探讨高渗盐水联合布地奈德雾化吸入治疗毛细支气管炎的临床效果。方法 90例毛细支气管炎患儿作为研究对象,将其随机分为常规组和实验组,每组45例。常规组患儿采用常规治疗方法 ,实验组患儿采用高渗盐水联合布地奈德雾化吸入进行治疗。对比两组患儿的治疗效果、缺氧症状改善情况、相关临床症状消失时间以及不良反应发生情况。结果实验组治疗总有效率为93.3%,高于常规组的77.8%,差异具有统计学意义(P<0.05)。两组患儿治疗前缺氧症状评分比较差异无统计学意义(P>0.05);治疗后,实验组患儿缺氧症状评分明显低于常规组,差异具有统计学意义(P<0.05)。经过治疗后,实验组患儿咳嗽消失时间、啰音消失时间、喘憋消失时间均短于常规组,差异均具有统计学意义(P<0.05)。实验组不良反应发生率为2.2%,低于常规组的13.3%,差异具有统计学意义(P<0.05)。结论高渗盐水联合布地奈德雾化吸入治疗毛细支气管炎具有良好的临床效果,值得在临床上进行推广。

Objective To study and explore the clinical effect of hypertonic saline combined with budesonide aerosol inhalation in the treatment of capillary bronchitis.Methods A total of90capillary bronchitis children as study subjects were randomly divided into conventional group and experimental group,with45cases in each group.The conventional group received conventional therapy,and the experimental group received hypertonic saline combined with budesonide aerosol inhalation for treatment.Comparison were made on treatment effect,hypoxia symptoms improvement situation,related clinical symptoms disappearance time and occurrence of adverse reactions in two groups.Results The experimental group had higher total treatment effective rate as93.3%than77.8%in the conventional group,and the difference had statistical significance(P<0.05).Both groups had no statistically significant difference in hypoxia symptom scores before treatment(P>0.05).After treatment,the experimental group had obviously lower hypoxia symptom scores than the conventional group,and the difference had statistical significance(P<0.05).After treatment,the experimental group had shorter cough disappearance time,rale disappearance time and asthma disappearance time than the conventional group,and the difference had statistical significance(P<0.05).The experimental group had lower incidence of adverse reactions as2.2%than13.3%in the conventional group,and the difference had statistical significance(P<0.05).Conclusion Combination of hypertonic saline and budesonide aerosol inhalation shows good clinical effect in treating capillary bronchitis,and it is worth clinical promotion.