改良XELOX方案对胃癌伴肝转移的治疗效果观察

Observation of curative effect by modified XELOX regimen for gastric cancer complicated with liver metastasis

目的探究改良XELOX方案对胃癌伴肝转移的治疗效果。方法 24例胃癌伴肝转移患者,所有患者均采用改良的XELOX方案,观察患者的中位总生存期(OS)、有效率、毒副反应。结果 24例胃癌伴肝转移患者中位OS为12个月,93%CI=(14.2,21.8);完全缓解、部分缓解、稳定、进展各2、10、8、4例,有效率为50%(12/24)。毒副反应包括恶心呕吐、疼痛、肝功能受损、白细胞减少和血小板减少、外周感觉神经毒性。结论胃癌伴肝转移,通过改良的XELOX方案治疗,临床效果较好,且能控制患者的药物毒副反应情况,值得临床方面广泛应用和推广。

Objective To investigate curative effect by modified XELOX regimen for gastric cancer complicated with liver metastasis.Methods A total of24gastric cancer complicated with liver metastasis patients all received modified XELOX regimen.Their median overall survival(OS),effective rate,toxic and side effects were observed.Results The24gastric cancer complicated with liver metastasis patients had median OS as12months with93%CI(14.2,21.8).There were2complete remission cases,10partial remission cases,8stable cases and4progress cases,with effective rate as50%(12/24).Their toxic and side effects included nausea and emesis,pain,liver function damage,leucopenia,thrombocytopenia and perisensory neurotoxicity.Conclusion Modified XELOX regimen shows excellent clinical effect in treating gastric cancer complicated with liver metastasis,and it can inhibit adverse drug reactions in patients.This method is worth widely clinical application and promotion.