环孢素A治疗儿童难治性肾病综合征疗效分析

Analysis on curative effect of cyclosporine A in the treatment of refractory nephrotic syndrome in children

目的分析环孢素A治疗儿童难治性肾病综合征的临床疗效。方法 40例难治性肾病综合征患儿,均给予环孢素A治疗,对患儿的临床治疗效果进行观察。结果 40例患儿治疗后,21例完全缓解,15例部分缓解,4例无效,临床治疗总有效率为90.0%(36/40)。治疗后,患儿的血肌酐、血尿素氮、血浆胆固醇、血浆白蛋白以及24 h尿蛋白水平均优于治疗前,差异均具有统计学意义(P<0.05)。治疗期间患儿没有发生高血压、肝肾功能损害等严重药物不良反应。结论在对儿童难治性肾病综合征患儿进行治疗时,应用环孢素A治疗能取得比较理想的效果,安全可靠,具有临床应用价值。

Objective To analyze the clinical curative effect of cyclosporine A in the treatment of refractory nephrotic syndrome in children.Methods A total of40refractory nephrotic syndrome children all received cyclosporine A for treatment,and their clinical treatment effect was observed.Results Among40children,there were21complete remission cases,15partial remission cases and4ineffective cases after treatment,with total clinical treatment effective rate as90.0%(36/40).After treatment,children had better serum creatinine,blood urea nitrogen,serum cholesterol,serum albumin,and24h urine protein levels than before treatment,and the difference had statistical significance(P<0.05).Children had no severe adverse reactions of hypertension,function lesion of liver and kidney during treatment.Conclusion Application of cyclosporine A shows an ideal effect in the treatment of refractory nephrotic syndrome children with safety and reliability,and it has clinical application value.