血栓弹力图对经皮冠状动脉介入治疗术后支架内再狭窄的预测价值

Predictive value of thrombelastogram to in-stent restenosis after percutaneous coronary intervention

目的研究血栓弹力图对经皮冠状动脉介入治疗(PCI)术后支架内再狭窄的预测价值。方法采用病例对照研究方法,选自2013年8月~2014年8月于安阳地区医院诊断为PCI术后1年内支架内再狭窄的患者作为病例组(18例),同时选择PCI术后1年未发生支架内再狭窄的患者作为对照组(50例),观察两组之间血小板聚集抑制率是否存在差异,与PCI术后再狭窄的发生有无统计学关联,是否为其发生的独立危险因素。结果病例组ADP途径血小板抑制率低于对照组,差异有统计学意义(P<0.05),与PCI术后再狭窄的发生独立相关,OR值为2.063。结论血小板抑制率与PCI术后支架内再狭窄发生独立相关,ADP途径血小板抑制率不达标为PCI术后患者发生再狭窄的独立危险因素。

Objective To study the predictive value of thrombelastogram(TEG)to in-stent restenosis after percutaneous coronary intervention(PCI).Methods The patients(n=18)with in-stent restenosis within1y after PCI(case group)and patients(n=50)without in-stent restenosis within1y after PCI(control group)were chosen by applying case-control study method from the Anyang Region Hospital from Aug.2013to Aug.2014.The difference in degree of platelet aggregation inhibition(DPAI)between2group,statistical correlation between DPAI and instent restenosis after PCI and whether DPAI was independent risk factor of in-stent restenosis or not were observed.Results DPAI in ADP way was lower in case group than that in control group(P<0.05),and it was independently correlated to the incidence of in-stent restenosis after PCI(OR=2.063).Conclusion DPAI is independently correlated to the incidence of in-stent restenosis after PCI,and lower DPAI in ADP way is an independent risk factor of in-stent restenosis after PCI.