氨水提取联合陶瓷膜超滤技术纯化甘草苷工艺研究

Study on Purification of Liquiritin by Using Ammonia Extraction and Ceramic Membrane Ultrafiltration Technology

目的建立一种适合于工业化生产的甘草苷提取纯化工艺路线。方法以甘草苷的提取率为指标,采用正交试验确定最佳提取条件;并以甘草苷的保留率和除杂率为指标,通过正交试验优选最佳超滤工艺参数。结果最佳提取条件为0.75%氨水24倍,提取3次,每次60 min,甘草苷平均提取率为72.3%。最佳超滤工艺参数:10 nm无机陶瓷膜,压力0.12 MPa,温度25℃,甘草苷平均保留率为98.9%,平均除杂率为23.3%。结论该工艺生产成本低,安全性好,适合工业化应用。

Objective To establish a suitable extraction and purification process line for industrial production ofliquiritin.Methods With the extraction rate of liquiritin as index,orthogonal test was used to determine the optimumconditions;with the retention rate of liquiritin and impurity removal rate as the indexes,orthogonal test was used tooptimize the best ultrafiltration process parameters.Results The optimum extraction conditions were:24times0.75%ammonia water,extracted three times,each time under60min.The liquiritin average extraction rate was72.3%.Thebest ultrafiltration process parameters were:10nm inorganic ceramic membrane,pressure of0.12MPa,temperatureof25℃.The liquiritin average retention rate was98.9%,and the average removal rate of impurity was23.3%.Conclusion This process has low production cost and good safety,and is suitable for industrial application.