不同剂量秋水仙碱在痛风急性发作期治疗中的疗效分析

Analysis on curative effect of different doses of colchicine in the treatment of acute attack of gout

目的对比研究不同剂量秋水仙碱用于痛风急性发作期的治疗效果。方法 141例痛风急性发作期患者,均采用秋水仙碱治疗,根据剂量不同分为低剂量组、中剂量组和高剂量组,每组47例。比较三组的治疗效果。结果低剂量组总有效率为82.9%、中剂量组总有效率为89.36%、高剂量组总有效率为93.62%,三组两两比较,差异均无统计学意义(P>0.05)。低剂量组不良反应发生率12.77%与中剂量组不良反应发生率27.66%均低于高剂量组74.47%,差异均具有统计学意义(P<0.05);低剂量组不良反应发生率低于中剂量组但差异无统计学意义(P>0.05)。结论低、中、高三种剂量秋水仙碱在治疗痛风急性发作期时,疗效相当,但低剂量在减少不良反应方面,更具优势。

Objective To compare and study the treatment effect of different doses of colchicineapplied in acute attack of gout.Methods A total of141acute attack of gout patients all receiving colchicinefor treatment were divided by different doses into low-dose group,medium-dose group and high-dose group,with47cases in each group.Treatment effect was compared in three groups.Results Low-dose group had totaleffective rate as82.9%,medium-dose group had total effective rate as89.36%,and high-dose group had totaleffective rate as93.62%.There was no statistically significant difference in pairwise comparison of three groups(P>0.05).Low-dose group had incidence of adverse reactions as12.77%,and medium-group had incidence ofadverse reactions as27.66%,which were all higher than74.47%in high-dose group,and their difference hadstatistical significance(P<0.05).Low-dose group had lower incidence of adverse reactions than medium-dosegroup,but their difference had no statistical significance(P>0.05).Conclusion Low,medium and high dosesof colchicine shows equal curative effect in treating acute attack of gout,but low doses has more advantages inreducing adverse reactions.