探讨兰索拉唑联合抗生素治疗酒精性消化溃疡的临床效果

Investigation of Clinical Effect of Lansoprazole Combined with Antibiotics in the Treatment of Alcoholic Peptic Ulcer

目的:分析及探索酒精性消化溃疡患者采用兰索拉唑与抗生素联合用药方案进行治疗的疗效。方法:收集咸宁市咸安中医医院2015年1月至2016年10月间接收的患酒精性消化溃疡的100例患者,参考随机双盲分组法将患者随机分成两组:参考组共有50例,给予奥美拉唑与抗生素联合用药方案进行治疗;治疗组共有50例,给予兰索拉唑与抗生素联合用药方案进行治疗。治疗完毕后详细地评估两组患者的治疗效果,且详细记录患者用药后的不良反应发生情况与复发情况。结果:治疗组患者治疗后的总有效率为(98.0%),较参考组患者的(80.0%)显著更高(P<0.05);治疗组患者的不良反应发生率较参考组显著更低(P<0.05);治疗组患者的复发率较参考组显著更低(P<0.05)。结论:酒精性消化溃疡患者采用兰索拉唑与抗生素联合用药方案进行治疗疗效显著,安全性高,复发少,值得借鉴。

Objective:To analyze and probe into the clinical effects of lansoprazole combined with antibiotics in the treatment of alcoholic peptic ulcer.Methods:100cases of patients with alcoholic peptic ulcer and who received treatment in our department from January2015to October2016werecollected,and randomly divided into two groups by the randomized double blind grouping methods.In the reference group,50cases were treatedwith omeprazole and antibiotics,while in the treatment group,50cases were treated with lansoprazole combined with antibiotic.Then,the treatmenteffects of two groups of patients after treatment were evaluated in detail,and the adverse reactions and recurrence of the patients were recorded indetail.Result:The total effective rate in the treatment group was98%,which was significantly higher than that in the reference group of80.00%(P<0.05);The incidence of adverse reactions in the treatment group was significantly lower than that in the reference group(P<0.05);The recurrence ratein the treatment group was significantly lower than that in the reference group(P<0.05).Conclusion:The clinical effects of lansoprazole combinedwith antibiotics in the treatment of alcoholic peptic ulcer are significant;the safety is higher,and the recurrence rate is less,thus it is worth learning.