右美托咪定用于老年患者围麻醉期的研究进展

Research progress of dexmedetomidine for elderly patients during anesthesia

老年人的自主神经系统发生退行性改变,对靶器官的调节能力下降,心功能储备降低,血流动力学不易保持稳定。如何在围麻醉期维持老年患者的血流动力学稳定,已成为临床研究的热点。右美托咪定作为一种新型的α2-肾上腺素能受体激动剂,具有良好的镇静、镇痛、抗焦虑、抗交感神经兴奋作用,已广泛应用于临床。本文阐述了老年患者围麻醉期应用右美托咪定的研究进展。

Degenerative changes in autonomic nervous system happen in elderly.The cardiac function reduces,theability of regulating the target organ decreases,and the stability of hemodynamics is not easy to maintain in old people.Howto maintain the hemodynamic stability of elderly patients during anesthesia has become the focus of clinical research.Dexmedetomidine,as a new type of2-alpha adrenergic agonist,has the function of anti-anxiety,sedation,analgesia andanti-sympathy,and which is wildly used in clinic.This article describes the research progress of dexmedetomidine used inelderly patients during anesthesia.