藏药“蒂达”6种原植物抗慢性肝损伤作用比较研究

Comparative Study on Six Kinds of Medicinal Plants in Tibetan Medicine "Dida" on Preventing Chronic Hepatic Injury

目的:比较藏药"蒂达"主要来源青叶胆等6种药用原植物对化学性肝损伤的保护效应。方法:采用四氯化碳(CCl4)造成小鼠化学性肝损伤模型,检测血清肝损伤指标来比较6种药用植物的保肝作用。结果:与模型组相比,6种药用植物均能显著性降低小鼠血清中的谷丙转氨酶(ALT)和谷草转氨酶(AST)的活性,升高总蛋白(TP)及减少总胆红素(TBI)的含量。与等剂量青叶胆相比,川西獐牙菜、椭圆叶花锚、印度獐牙菜、紫红獐牙菜和唐古特虎耳草降低ALT、AST、TBI和升高TP的能力差异无统计学意义。结论:青叶胆和"蒂达"其他来源的5种药用植物对于化学性肝损伤的保护效应差异不显著。

Objective:To compare the protective effect of six kinds of medicinal plants in Tibetan medicine"Dida"on chemical hepatic injury.Methods:Carbon tetrachloride(CCl4)was used to cause chemical hepatic injury in mice to form the model group.The serum hepatic injury index was used to detected the hepatoprotective effect of six medicinal plants of liver injury induced by serum indicators to compare the effect of6species of medicinal plants.Results:Compared with the model group,six medicinal plants can significantly reduce serum alanine transaminase(ALT)and aspartate aminotransferase(AST)activity,and increase total protein(TP)and total bilirubin reduction(TBI)content.Compared with equivalent dose Swertia mileensis,Swertia chirayita(Roxb.ex Flemi)Karsten,Swertia mussotii,Swertia punicea,Halenia elliptica,Saxifraga tangutica reduced ALT,AST,TBI and increased TP without significant difference.Conclusion:Hepatoprotective effect on chemical hepatic injury of Swertia mileensis and other five kinds of medicinal plants in"Dida"had no significant difference.